全部文献期刊学位论文会议报纸专利标准年鉴图书|学者科研项目
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作者:Jacob L. Bitterman , Jay H. Chung
来源:[J].Cellular and Molecular Life Sciences(IF 5.615), 2015, Vol.72 (8), pp.1473-1488Springer
摘要:Abstract(#br)Resveratrol, a polyphenol found in a number of plant-based foods such as red wine, has received a great deal of attention for its diverse array of healthful effects. Beneficial effects of resveratrol are diverse; they include improvement of mitochondrial function, pr...
作者:... Michele D. Allen , Timothy J. Hagen , Jay H. Chung
来源:[J].Biochemical and Biophysical Research Communications(IF 2.406), 2018, Vol.506 (4), pp.1059-1064Elsevier
摘要:Abstract(#br)Aims(#br)Therapies that recapitulate the health benefits of caloric restriction in older adults are needed. Phosphodiesterase 4 inhibitors demonstrate such promise. We examined their effects on body weight and composition, physical and cognitive function in aged mice...
作者:Jay H. Chung , Vincent Manganiello , Jason R.B. Dyck
来源:[J].Trends in Cell Biology(IF 11.721), 2012, Vol.22 (10), pp.546-554Elsevier
摘要:It is widely believed that calorie restriction (CR) can extend the lifespan of model organisms and protect against aging-related diseases. A potential CR mimetic is resveratrol, which may have beneficial effects against numerous diseases such as type 2 diabetes, cardiovascular di...
作者:... Ji-Won Lee , Jay H. Chung , Michael J. Quon
来源:[J].The Journal of Nutritional Biochemistry(IF 4.552), 2012, Vol.23 (9), pp.1134-1145Elsevier
摘要:Abstract(#br)Epigallocatechin gallate (EGCG), the major polyphenol in green tea, acutely stimulates production of nitric oxide (NO) from vascular endothelium to reduce hypertension and improve endothelial dysfunction in spontaneously hypertensive rats. Herein, we explored ad...
作者:... Alex B. Burgin , Vincent Manganiello , Jay H. Chung
来源:[J].Cell(IF 31.957), 2012, Vol.148 (3), pp.421-433Elsevier
摘要:Summary(#br)Resveratrol, a polyphenol in red wine, has been reported as a calorie restriction mimetic with potential antiaging and antidiabetogenic properties. It is widely consumed as a nutritional supplement, but its mechanism of action remains a mystery. Here, we report t...
作者:... Yoe-Sik Bae , Jay H. Chung , Jeanho Yun
来源:[J].BBA - Molecular Cell Research(IF 4.808), 2011, Vol.1813 (6), pp.1230-1238Elsevier
摘要:Abstract(#br)Chk1 plays a key role in the DNA replication checkpoint and in preserving genomic integrity. Previous studies have shown that reduced Chk1 function leads to defects in the checkpoint response and is closely associated with tumorigenesis. Here, we report that glu...
作者:... Jae-Won Jung , Myung K. Kim , Jay H. Chung
来源:[J].Molecular Cell(IF 15.28), 2011, Vol.44 (2), pp.203-213Elsevier
摘要:Summary(#br)In mammals, the Sirtuins are composed of seven Sir2 orthologs (Sirt1 – 7) with a conserved deacetylase core that utilizes NAD + as a cofactor. Interestingly, the deacetylase core of Sirt1 by itself has no catalytic activity. We found within the C-terminal domain ...
作者:Jay H. Chung , Jimmy D. Dikeakos
来源:[J].Cell Reports, 2014, Vol.8 (5), pp.1545-1557Elsevier
摘要:Summary(#br)SIRT1 regulates the DNA damage response by deacetylating p53, thereby repressing p53 transcriptional output. Here, we demonstrate that the sorting protein PACS-2 regulates SIRT1-mediated deacetylation of p53 to modulate the DNA damage response. PACS-2 knockdown c...
作者:... Jong-Young Kwak , Jay H. Chung , Jeanho Yun
来源:[J].Biochemical and Biophysical Research Communications(IF 2.406), 2007, Vol.360 (2), pp.483-489Elsevier
摘要:Abstract(#br)Protein acetylation modification has been implicated in many cellular processes but the direct evidence for the involvement of protein acetylation in signal transduction is very limited. In the present study, we found that an alkylating agent methyl methanesulfonate ...

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