全部文献期刊学位论文会议报纸专利标准年鉴图书|学者科研项目
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作者:Jason S. Lewis , Brian M. Zeglis
来源:[J].EJNMMI Research, 2017, Vol.7 (1)Springer
摘要:Pretargeting-based approaches are being investigated for radioimmunoimaging and therapy applications to reduce the effective radiation burden to the patient. To date, only a few studies have used short-lived radioisotopes for pretargeting of antibodies, and such examples with int...
作者:... Jan Grimm , Jason S. Lewis , Thomas Reiner
来源:[J].Scientific Reports(IF 2.927), 2019, Vol.9 (1), pp.1-12DOAJ
摘要:Abstract Breast cancer is the most common type of malignant growth in women. Early detection of breast cancer, as well as the identification of possible metastatic spread poses a significant challenge because of the structural and genetic heterogeneity that occurs during the prog...
作者:... Sean D. Carlin , Jason S. Lewis , Nerissa T. Viola-Villegas
来源:[J].Scientific Reports(IF 2.927), 2018, Vol.8 (1), pp.1-13DOAJ
摘要:Abstract Tumor resistance to treatment paved the way toward the development of single agent drugs that target multiple molecular signatures amplified within the malignancy. The discovered crosstalk between EGFR and HER3 as well as the role of HER3 in mediating EGFR resistance mad...
作者:... Kathryn M. Tully , John T. Poirier , Jason S. Lewis
来源:[J].Nuclear Medicine and Biology(IF 2.517), 2019, Vol.71, pp.32-38Elsevier
摘要:Abstract(#br)Introduction(#br)Determination of the target-binding fraction (TBF) of radiopharmaceuticals using cell-based assays is prone to inconsistencies arising from several intrinsic and extrinsic factors. Here, we report a cell-free quantitative method of analysis to d...
作者:Jason S. Lewis , Naga Vara Kishore Pillarsetty ...
来源:[J].EJNMMI Research, 2018, Vol.8 (1), pp.1-10Springer
摘要:Abstract(#br) Background(#br)The folate receptor α (FRα)-targeting antibody-drug conjugate (ADC), IMGN853, shows great antitumor activity against FRα-expressing tumors in vivo, but patient selection and consequently therapy outcome are based on immunohistochemistry. The aim ...
作者:... Wolfgang W. Scholz , Jason S. Lewis , Jacob L. Houghton
来源:[J].Molecular Imaging and Biology(IF 3.095), 2018, Vol.20 (5), pp.808-815Springer
摘要:Abstract(#br) Purpose(#br)Tumor-specific molecular imaging is an important tool for assessing disease burden and treatment response. CA19.9 is an important tumor-specific marker in several malignancies, including urothelial carcinoma. [ 89 Zr]DFO-HuMab-5B1 (MVT-2163) is a CA...
作者:Jason S. Lewis , Michael J. Adam
来源:[J].J. Am. Chem. Soc., 2013, Vol.135 (34), pp.12707鈥?2721ACS
摘要:† Medicinal Inorganic Chemistry Group, Department of Chemistry, University of British Columbia, 2036 Main Mall, Vancouver, British Columbia, Canada, V6T 1Z1 ... The analytical thin-layer chromatography (TLC) plates were aluminum-backed ultrapure silica gel (Siliaplate, 60 Å ...
作者:... Thomas Reiner , Mauri A. Kostiainen , Jason S. Lewis
来源:[J].Nuclear Medicine and Biology(IF 2.517), 2020, Vol.80-81, pp.1-12Elsevier
摘要:Abstract(#br)Methods(#br)We have developed a nuclear and fluorescence labeling strategy for nanocrystalline cellulose (CNC), an emerging biomaterial with versatile chemistry and facile preparation from renewable sources. We modified CNC through 1,1′-carbonyldiimidazole (CDI)...

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