全部文献期刊学位论文会议报纸专利标准年鉴图书|学者科研项目
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作者:Jason S. Lewis , Brian M. Zeglis
来源:[J].EJNMMI Research, 2017, Vol.7 (1)Springer
摘要:Pretargeting-based approaches are being investigated for radioimmunoimaging and therapy applications to reduce the effective radiation burden to the patient. To date, only a few studies have used short-lived radioisotopes for pretargeting of antibodies, and such examples with int...
作者:Jason S. Lewis , Oleg A. Andreev ...
来源:[J].Trends in Biotechnology(IF 9.66), 2017, Vol.35 (7), pp.653-664Elsevier
摘要:Acidity is a biomarker of cancer that is not subject to the blunting clonal selection effects that reduce the efficacy of other biomarker technologies, such as antibody targeting. The pH (low) insertion peptides (pHLIP ® s) provide new opportunities for targeting acidic tiss...
作者:... Lolkje Abma , Kelly E. Henry , Jason S. Lewis
来源:[J].Cancer Letters(IF 4.258), 2018, Vol.419, pp.139-151Elsevier
摘要:Abstract(#br)The Human Epidermal Growth Factor Receptor (ErbB/HER) family - EGFR/HER1, ErbB-2/HER2, ErbB-3/HER3, and ErbB-4/HER4 - play a key role in tumor development. Moreover, positive status of HER2 and specific mutations of EGFR are necessary to initiate HER2 directed and EG...
作者:... Kathryn M. Tully , John T. Poirier , Jason S. Lewis
来源:[J].Nuclear Medicine and Biology(IF 2.517), 2019, Vol.71, pp.32-38Elsevier
摘要:Abstract(#br)Introduction(#br)Determination of the target-binding fraction (TBF) of radiopharmaceuticals using cell-based assays is prone to inconsistencies arising from several intrinsic and extrinsic factors. Here, we report a cell-free quantitative method of analysis to d...
作者:Jason S. Lewis , Naga Vara Kishore Pillarsetty ...
来源:[J].EJNMMI Research, 2018, Vol.8 (1), pp.1-10Springer
摘要:Abstract(#br) Background(#br)The folate receptor α (FRα)-targeting antibody-drug conjugate (ADC), IMGN853, shows great antitumor activity against FRα-expressing tumors in vivo, but patient selection and consequently therapy outcome are based on immunohistochemistry. The aim ...
作者:... Wolfgang W. Scholz , Jason S. Lewis , Jacob L. Houghton
来源:[J].Molecular Imaging and Biology(IF 3.095), 2018, Vol.20 (5), pp.808-815Springer
摘要:Abstract(#br) Purpose(#br)Tumor-specific molecular imaging is an important tool for assessing disease burden and treatment response. CA19.9 is an important tumor-specific marker in several malignancies, including urothelial carcinoma. [ 89 Zr]DFO-HuMab-5B1 (MVT-2163) is a CA...
作者:Jason S. Lewis , Michael J. Adam
来源:[J].J. Am. Chem. Soc., 2013, Vol.135 (34), pp.12707鈥?2721ACS
摘要:† Medicinal Inorganic Chemistry Group, Department of Chemistry, University of British Columbia, 2036 Main Mall, Vancouver, British Columbia, Canada, V6T 1Z1 ... The analytical thin-layer chromatography (TLC) plates were aluminum-backed ultrapure silica gel (Siliaplate, 60 Å ...
作者:... Michael J. Adam , Chris Orvig , Jason S. Lewis
来源:[J].Nuclear Medicine and Biology(IF 2.517), 2016, Vol.43 (9), pp.566-576Elsevier
摘要:Abstract(#br)Objectives(#br)To compare the radiolabeling performance, stability, and practical efficacy of the chelators CHX-A″-DTPA and H 4 octapa with the therapeutic radiometal 90 Y.(#br)Methods(#br)The bifunctional chelators p -SCN-Bn-H 4 octapa and p -SCN-Bn-CHX-A″-DTPA...

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