全部文献期刊会议图书|学者科研项目
中外文文献  中文文献  外文文献
作者:Jaroslav Albert , Rudi Labarbe ...
来源:[J].Physica Medica(IF 1.167), 2019, Vol.64, pp.33-39
摘要:Abstract(#br)Proton radiotherapy has a potential to provide an effective cancer treatment while sparing greater volume of healthy tissue than the conventional X-ray based radiotherapy. However, in lungs this potential is hindered by motion due to breathing. An important quantity ...
作者:Jaroslav Albert , Marianne Rooman
来源:[J].PLoS ONE(IF 3.73), 2017, Vol.7 (11)
摘要:Turning genes on and off is a mechanism by which cells and tissues make phenotypic decisions. Gene network motifs capable of supporting two or more steady states and thereby providing cells with a plurality of possible phenotypes are referred to as genetic switches. Modeled on th...
作者:Jaroslav Albert , Marianne Rooman
来源:[J].PLoS ONE(IF 3.73), 2017, Vol.10 (7)
摘要:One of the functions of the cell nucleus is to help regulate gene expression by controlling molecular traffic across the nuclear envelope. Here we investigate, via stochastic simulation, what effects, if any, does segregation of a system into the nuclear and cytoplasmic compartme...
作者:Jaroslav Albert , Yves Dehouck
来源:[J].PLoS ONE(IF 3.73), 2017, Vol.6 (12)
摘要:Available DNA microarray time series that record gene expression along the developmental stages of multicellular eukaryotes, or in unicellular organisms subject to external perturbations such as stress and diauxie, are analyzed. By pairwise comparison of the gene expression profi...
作者:Marianne Rooman , Jaroslav Albert , Mitia Duerinckx
来源:[J].Journal of Theoretical Biology(IF 2.351), 2014, Vol.354, pp.113-123
摘要:Abstract(#br)Cell systems consist of a huge number of various molecules that display specific patterns of interactions, which have a determining influence on the cell׳s functioning. In general, such complexity is seen to increase with the complexity of the organism, with a c...
作者:Jaroslav Albert
来源:[J].Journal of Mathematical Biology(IF 2.366), 2019, Vol.79 (6-7), pp.2211-2236
摘要:Abstract(#br)Stochastic fluctuations in the copy number of gene products have perceivable effects on the functioning of gene regulatory networks (GRNs). The master equation (ME) provides a theoretical basis for studying such effects. However, solving the ME can be a task that ran...
作者:Jaroslav Albert , Marianne Rooman
来源:[J].Journal of Mathematical Biology(IF 2.366), 2016, Vol.72 (1-2), pp.157-169
摘要:Abstract(#br)We propose a fast and accurate method of obtaining the equilibrium mono-modal joint probability distributions for multimeric systems. The method necessitates only two assumptions: the copy number of all species of molecule may be treated as continuous; and, the proba...
作者:Jaroslav Albert
来源:[J].PLOS ONE(IF 3.73), 2016, Vol.11 (3)
摘要:Modeling stochastic behavior of chemical reaction networks is an important endeavor in many aspects of chemistry and systems biology. The chemical master equation (CME) and the Gillespie algorithm (GA) are the two most fundamental approaches to such modeling; however, each o...
作者:Jaroslav Albert , Marianne Rooman
来源:[J].PLOS ONE(IF 3.73), 2015, Vol.10 (7)
摘要:One of the functions of the cell nucleus is to help regulate gene expression by controlling molecular traffic across the nuclear envelope. Here we investigate, via stochastic simulation, what effects, if any, does segregation of a system into the nuclear and cytoplasmic compartme...

我们正在为您处理中,这可能需要一些时间,请稍等。

资源合作:cnki.scholar@cnki.net, +86-10-82896619   意见反馈:scholar@cnki.net

×