全部文献期刊学位论文会议报纸专利标准年鉴图书|学者科研项目
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作者:Jan-Peer Elshoff , Jens-Otto Andreas ...
来源:[J].Clinical Therapeutics(IF 2.23), 2015, Vol.37 (4), pp.902-912Elsevier
摘要:Abstract(#br)Purpose(#br)Rotigotine, a nonergolinic dopamine receptor agonist, is a once-daily transdermal patch developed for the treatment of Parkinson’s disease and restless legs syndrome. The objective of the present study was to determine the pharmacokinetic characteris...
作者:Jan-Peer Elshoff , Willi Cawello ...
来源:[J].Drugs(IF 4.633), 2015, Vol.75 (5), pp.487-501Springer
摘要:Abstract(#br)This narrative review reports on the pharmacological and pharmacokinetic properties of rotigotine, a non-ergolinic D3/D2/D1 dopamine receptor agonist approved for the treatment of early- and advanced-stage Parkinson’s disease (PD...
作者:Jan-Peer Elshoff , Marina Braun ...
来源:[J].Clinical Therapeutics(IF 2.23), 2012, Vol.34 (4), pp.966-978Elsevier
摘要:Abstract(#br)Background(#br)The dopamine agonist rotigotine is formulated in a transdermal delivery system (patch) for once-daily application. It has been reported as efficacious in the treatment of idiopathic Parkinson's disease (PD) and restless legs syndrome.(#br)Objectiv...
作者:... Teresa Gasalla , Sami Elmoufti , Jan-Peer Elshoff
来源:[J].European Journal of Paediatric Neurology(IF 1.982), 2019Elsevier
摘要:Abstract(#br)Objective(#br)To evaluate long-term safety and tolerability of adjunctive brivaracetam (BRV) in children with epilepsy.(#br)Methods(#br)This was an interim analysis (cut-off March 15, 2017) of pooled data from two open-label, single-arm, multicentre trials. N012...
作者:Jan-Peer Elshoff , John Hudson ...
来源:[J].Sleep Medicine(IF 3.487), 2016Elsevier
摘要:Abstract(#br)Objective(#br)To investigate the pharmacokinetics (PK) of rotigotine transdermal system in adolescents with moderate-to-severe idiopathic restless legs syndrome (RLS).(#br)Methods(#br)This multicenter, open-label, dose-escalation study enrolled patients ≥13 to <...
作者:Jan-Peer Elshoff , Bernd Meibohm ...
来源:[J].Journal of the American College of Cardiology(IF 14.086), 2005, Vol.46 (7), pp.1322-1330Elsevier
摘要:Objectives(#br)The objective of this study was to develop age-specific dosage guidelines for sotalol in children with supraventricular tachycardia (SVT) based on a population pharmacokinetic covariate analysis, clinical trial simulations, and pharmacodynamics.(#br)Background...
作者:... Willi Cawello , Josef Waitzinger , Jan-Peer Elshoff
来源:[J].Clinical Drug Investigation(IF 1.915), 2015, Vol.35 (4), pp.255-265Springer
摘要:Abstract(#br) Background and Objective(#br)Age- and sex-related differences in body composition could affect the pharmacokinetic parameters of administered drugs. The purpose of this post hoc analysis was to investigate the influences of age and sex on the pharmacokinetics o...
作者:Jan-Peer Elshoff , Takeuchi Masahiro ...
来源:[J].European Journal of Drug Metabolism and Pharmacokinetics(IF 0.944), 2016, Vol.41 (4), pp.353-362Springer
摘要:Abstract(#br)Rotigotine is a dopamine receptor agonist indicated for the treatment of Parkinson’s disease and moderate-to-severe restless legs syndrome. Continuous transdermal delivery of rotigotine via a silicon-based patch maintains stable plasma concentrations over 24 h. ...
作者:Jan-Peer Elshoff , Junji Ikeda
来源:[J].Clinical Drug Investigation(IF 1.915), 2014, Vol.34 (2), pp.95-105Springer
摘要:Abstract(#br) Background and Objectives(#br)Rotigotine is a dopamine receptor agonist with activity across the D 1 through to D 5 receptors as well as select serotonergic and adrenergic sites; continuous transdermal delivery of rotigotine with replacement of the patch once d...

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