全部文献期刊会议图书|学者科研项目
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作者:... Teresa Gasalla , Sami Elmoufti , Jan-Peer Elshoff
来源:[J].European Journal of Paediatric Neurology(IF 1.982), 2020, Vol.25, pp.68-76
摘要:Abstract(#br)Objective(#br)To evaluate long-term safety and tolerability of adjunctive brivaracetam (BRV) in children with epilepsy.(#br)Methods(#br)This was an interim analysis (cut-off March 15, 2017) of pooled data from two open-label, single-arm, multicentre trials. N012...
作者:Jan-Peer Elshoff , John Hudson ...
来源:[J].Sleep Medicine(IF 3.487), 2017, Vol.32, pp.48-55
摘要:Abstract(#br)Objective(#br)To investigate the pharmacokinetics (PK) of rotigotine transdermal system in adolescents with moderate-to-severe idiopathic restless legs syndrome (RLS).(#br)Methods(#br)This multicenter, open-label, dose-escalation study enrolled patients ≥13 to <...
作者:... Erwin Surmann , Xiaojuan Guo , Jan-Peer Elshoff
来源:[J].Clinical Therapeutics(IF 2.23), 2018, Vol.40 (7), pp.1108-1121.e8
摘要:ABSTRACT(#br)Purpose(#br)The pharmacokinetic (PK) profile of the rotigotine transdermal patch is well characterized in Caucasian patients with Parkinson's disease (PD) but not in Chinese subjects. This article reports the PK variables, safety, and tolerability of the rotigot...
作者:Jan-Peer Elshoff , Jens-Otto Andreas ...
来源:[J].Clinical Therapeutics(IF 2.23), 2015, Vol.37 (4), pp.902-912
摘要:Abstract(#br)Purpose(#br)Rotigotine, a nonergolinic dopamine receptor agonist, is a once-daily transdermal patch developed for the treatment of Parkinson’s disease and restless legs syndrome. The objective of the present study was to determine the pharmacokinetic characteris...
作者:Jan-Peer Elshoff , Stephanie Läer
来源:[J].Journal of Pharmacological and Toxicological Methods(IF 2.15), 2005, Vol.52 (2), pp.251-259
摘要:Abstract(#br)Introduction: Limited blood volume is a major problem in pharmacokinetic investigations in specific populations, e.g. children. Intravenous microdialysis might help to obtain improved data sets as it is already successfully done in small animals. Since quantific...
作者:Jan-Peer Elshoff , Marina Braun ...
来源:[J].Clinical Therapeutics(IF 2.23), 2012, Vol.34 (4), pp.966-978
摘要:Abstract(#br)Background(#br)The dopamine agonist rotigotine is formulated in a transdermal delivery system (patch) for once-daily application. It has been reported as efficacious in the treatment of idiopathic Parkinson's disease (PD) and restless legs syndrome.(#br)Objectiv...
作者:Jan-Peer Elshoff , Bernd Meibohm ...
来源:[J].Journal of the American College of Cardiology(IF 14.086), 2005, Vol.46 (7), pp.1322-1330
摘要:Objectives(#br)The objective of this study was to develop age-specific dosage guidelines for sotalol in children with supraventricular tachycardia (SVT) based on a population pharmacokinetic covariate analysis, clinical trial simulations, and pharmacodynamics.(#br)Background...
作者:Jan-Peer Elshoff , Willi Cawello ...
来源:[J].Drugs(IF 4.633), 2015, Vol.75 (5), pp.487-501
摘要:Abstract(#br)This narrative review reports on the pharmacological and pharmacokinetic properties of rotigotine, a non-ergolinic D3/D2/D1 dopamine receptor agonist approved for the treatment of early- and advanced-stage Parkinson’s disease (PD...
作者:... Willi Cawello , Josef Waitzinger , Jan-Peer Elshoff
来源:[J].Clinical Drug Investigation(IF 1.915), 2015, Vol.35 (4), pp.255-265
摘要:Abstract(#br) Background and Objective(#br)Age- and sex-related differences in body composition could affect the pharmacokinetic parameters of administered drugs. The purpose of this post hoc analysis was to investigate the influences of age and sex on the pharmacokinetics o...
作者:Jan-Peer Elshoff , Takeuchi Masahiro ...
来源:[J].European Journal of Drug Metabolism and Pharmacokinetics(IF 0.944), 2016, Vol.41 (4), pp.353-362
摘要:Abstract(#br)Rotigotine is a dopamine receptor agonist indicated for the treatment of Parkinson’s disease and moderate-to-severe restless legs syndrome. Continuous transdermal delivery of rotigotine via a silicon-based patch maintains stable plasma concentrations over 24 h. ...

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