全部文献期刊会议图书|学者科研项目
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作者:... Roger Perkins , Wen Zou , James J. Chen
来源:[J].BMC Public Health(IF 2.076), 2016, Vol.16 (1)Springer
摘要:Abstract(#br) Background(#br)Both adolescent substance use and adolescent depression are major public health problems, and have the tendency to co-occur. Thousands of articles on adolescent substance use or depression have been published. It is labor intensive and time consuming ...
作者:Tzu-Pin Lu , James J. Chen
来源:[J].BMC Medical Research Methodology(IF 2.211), 2015, Vol.15 (1)Springer
摘要:Abstract(#br) Background(#br)Advances in molecular technology have shifted new drug development toward targeted therapy for treatments expected to benefit subpopulations of patients. Adaptive signature design (ASD) has been proposed to identify the most suitable target patient su...
作者:James J. Chen , Roger Perkins ...
来源:[J].BMC Bioinformatics(IF 3.024), 2016, Vol.17 (1)Springer
摘要:Abstract(#br) Background(#br)Next-generation sequencing (NGS) technologies have provided researchers with vast possibilities in various biological and biomedical research areas. Efficient data mining strategies are in high demand for large scale comparative and evolutional studie...
作者:James J. Chen , Frederick A. Beland ...
来源:[J].International Journal of Molecular Sciences(IF 2.464), 2011, Vol.12 (7), pp.4609-4624DOAJ
摘要:Drug-induced liver injury (DILI) is the primary adverse event that results in the withdrawal of drugs from the market and a frequent reason for the failure of drug candidates in the pre-clinical or clinical phases of drug development. This paper presents an approach for iden...
作者:James J. Chen , Janet A. Springer ...
来源:[J].Toxicology(IF 4.017), 1995, Vol.105 (2), pp.199-208Elsevier
摘要:Abstract(#br)The excess cancer risk that might result from exposure to a mixture of chemical carcinogens usually is estimated with data from experiments conducted on individual chemicals. An upper bound on the total excess risk is estimated commonly by summing individual upp...
作者:Jing-Shiang Hwang , James J. Chen
来源:[J].Risk Analysis(IF 2.278), 1999, Vol.19 (6), pp.1071-1076Springer
摘要:Abstract(#br)The estimation of health risks from exposure to a mixture of chemical carcinogens is generally based on the combination of information from several available single compound studies. The current practice of directly summing the upper bound risk estimates of individua...
作者:... Grace I. Lin , James J. Chen , Kishore Chaudhry
来源:[J].Disease Markers(IF 2.14), 2013, Vol.35 (6)Hindawi
摘要:Numerous studies have demonstrated sex differences in drug reactions to the same drug treatment, steering away from the traditional view of one-size-fits-all medicine. A premise of this study is that the sex of a patient influences difference in disease characteristics and risk f...
作者:James J. Chen , Yi Tsong
来源:[J].Journal of Biopharmaceutical Statistics(IF 0.728), 1997, Vol.7 (2), pp.259-270Taylor & Francis
摘要:In dissolution testing, multiple dissolution measurements at specific time points are used to obtain the dissolution characteristics for most extended- release and some immediate-release drug products. This paper presents a general procedure for defining specifications by a multi...
作者:James J. Chen , Jing-Shiang Hwang , Yi Tsong
来源:[J].Journal of Biopharmaceutical Statistics(IF 0.728), 1995, Vol.5 (1), pp.131-140Taylor & Francis
摘要:This paper proposes a normal mixed effects model for stability analysis. An EM algorithm is developed to compute the maximum likelihood estimates of regression coefficients of the fixed effects and random effects, and variance components. The likelihood ratio test is used for the...

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