全部文献期刊会议图书|学者科研项目
中外文文献  中文文献  外文文献
作者:Heidi N. Hilton , Christine L. Clarke , J. Dinny Graham
来源:[J].Molecular and Cellular Endocrinology(IF 4.039), 2018, Vol.466, pp.2-14
摘要:Abstract(#br)The ovarian hormones estrogen and progesterone are master regulators of the development and function of a broad spectrum of human tissues, including the breast, reproductive and cardiovascular systems, brain and bone. Acting through the nuclear estrogen (ER) and prog...
作者:J. Dinny Graham , Matthew A. Powell ...
来源:[J].Gynecologic Oncology(IF 3.929), 2015, Vol.138 (3), pp.663-667
摘要:Abstract(#br)Objective(#br)Hormonal therapy is generally reserved for patients with endometrial cancers that fail cytotoxic chemotherapy, but there is a lack of sufficiently sensitive diagnostics to identify potential responders. We sought to develop a diagnostic technique t...
作者:J. Dinny Graham , Christine Yeates ...
来源:[J].Journal of Steroid Biochemistry and Molecular Biology(IF 3.984), 1996, Vol.56 (1), pp.93-98
摘要:Abstract(#br)The human progesterone receptor (PR) is a ligand-activated nuclear transcription factor which mediates progesterone action in target tissues. Two PR proteins, PR A (81–83 kDa) and PR B (116–120 kDa), have been described and different physiological activities asc...
作者:Matloob Khushi , Christine L. Clarke , J. Dinny Graham
来源:[J].PeerJ, 2014, Vol.2
摘要:Chromatin factors interact with each other in a cell and sequence-specific manner in order to regulate transcription and a wealth of publically available datasets exists describing the genomic locations of these interactions. Our recently published BiSA (Binding Sites Analys...
作者:... Karen Byth , J. Dinny Graham , Christine L. Clarke
来源:[J].Breast Cancer Research and Treatment(IF 4.469), 2015, Vol.151 (2), pp.309-318
摘要:Abstract(#br)Progesterone receptor (PR) function, while essential in normal human breast, is also implicated in breast cancer risk. The two progesterone receptors, PRA and PRB, are co-expressed at equivalent levels in normal breast, but early in carcinogenesis normal levels ...
作者:J. Dinny Graham , Patricia A. Mote ...
来源:[J].Journal of Mammary Gland Biology and Neoplasia(IF 7.524), 2009, Vol.14 (4), pp.367-379
摘要:Abstract(#br)Retention of hormone responsiveness in primary culture models of human breast is essential for studies aimed at understanding the mechanisms of action of the ovarian hormones in the human breast. In this chapter we describe the development of a culture model of prima...
作者:J. Dinny Graham , Ellis Patrick ...
来源:[J].Nature Communications(IF 10.015), 2019, Vol.10 (1), pp.1-15
摘要:Composition and function of immune populations at barrier surfaces is crucial for response to infection. Here, the authors identify a population of dendritic cells in human epidermis, abundant in anogenital epithelia and distinct from Langerhans cells by surface phenotype and by ...
作者:J. Dinny Graham , George E. O. Muscat ...
来源:[J].Breast Cancer Research and Treatment(IF 4.469), 2013, Vol.142 (1), pp.211-223
摘要:Abstract(#br)The interaction between breast tumor epithelial and stromal cells is vital for initial and recurrent tumor growth. While breast cancer-associated stromal cells provide a favorable environment for proliferation and metastasis, the molecular mechanisms contributin...
作者:J. Dinny Graham , Ellis Patrick ...
来源:[J].Nature Communications(IF 10.015), 2019, Vol.10 (2), pp.658-660
摘要:Abstract(#br)Langerhans cells (LC) are thought to be the only mononuclear phagocyte population in the epidermis where they detect pathogens. Here, we show that CD11c+ dendritic cells (DCs) are also present. These cells are transcriptionally similar to dermal cDC2 but a...

我们正在为您处理中,这可能需要一些时间,请稍等。

资源合作:cnki.scholar@cnki.net, +86-10-82896619   意见反馈:scholar@cnki.net

×