全部文献期刊学位论文会议报纸专利标准年鉴图书|学者科研项目
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作者:Isabella Orienti , Mirella Falconi ...
来源:[J].Nanomedicine: Nanotechnology, Biology, and Medicine(IF 6.93), 2015, Vol.11 (2), pp.263-273Elsevier
摘要:Abstract(#br)The present study deals with the preparation of albumin nanocapsules containing fenretinide and their evaluation in experimental models of human non-small cell lung cancer. These nanocapsules showed enhanced antitumor activity with respect to free fenretinide due to ...
作者:Isabella Orienti , Mirella Falconi ...
来源:[J].Pharmaceutical Research(IF 4.742), 2016, Vol.33 (11), pp.2722-2735Springer
摘要:Abstract(#br) Purpose(#br)We describe a novel class of antitumor amphiphilic amines (RCn) based on a tricyclic amine hydrophilic head and a hydrophobic linear alkyl tail of variable length.(#br) Methods(#br)We tested the lead compound, RC16, for cytotoxicity and mechanism of cell...
作者:Isabella Orienti , Guendalina Zuccari ...
来源:[J].Nanomedicine: Nanotechnology, Biology, and Medicine(IF 6.93), 2012, Vol.8 (6), pp.880-890Elsevier
摘要:Abstract(#br)This study reports on the preparation and evaluation of amphiphilic macromolecules based on branched polyethylene glycol covalently linked with alkyl hydrocarbon chains. These macromolecules easily dissolved in an aqueous environment, with formation of micellar nanoa...
作者:Isabella Orienti , Federica Bigucci ...
来源:[J].European Journal of Pharmaceutics and Biopharmaceutics(IF 3.826), 2002, Vol.54 (2), pp.229-233Elsevier
摘要:Abstract(#br)Among the different methods used to increase the aqueous drug solubility, the preparation of a solid dispersion with a soluble carrier represents an interesting formulative approach. We substituted polyvinylalcohol with triethyleneglycolmonoethylether and obtain...
作者:... Federica Bigucci , Isabella Orienti , Vittorio Zecchi
来源:[J].European Journal of Pharmaceutics and Biopharmaceutics(IF 3.826), 2003, Vol.56 (3), pp.401-405Elsevier
摘要:Abstract(#br)The objective of this study was to evaluate the in vitro characteristics of polyvinylalcohol 10,000 (PVA10,000) and polyvinylalcohol 15,000 (PVA15,000) substituted with different alkyl chains (Iodododecane, Bromotetradecane) and crosslinked with Bis-chloro-ethox...
作者:... Federica Bigucci , Isabella Orienti , Vittorio Zecchi
来源:[J].European Journal of Pharmaceutics and Biopharmaceutics(IF 3.826), 2003, Vol.55 (2), pp.199-202Elsevier
摘要:Abstract(#br)Delivery of drugs to the large bowel has been extensively investigated during the last decade. The aim of this work was to study polymethacrylic acid-co-methylmethacrylate substituted with fatty acids (lauric, myristic, palmitic and stearic) at 20% substitution ...
作者:Isabella Orienti , Franca Formelli ...
来源:[J].Journal of Pharmacy and Pharmacology(IF 2.033), 2012, Vol.64 (2), pp.228-236Wiley
摘要:Abstract(#br)Objectives The major limitation to successful chemotherapy of neuroblastoma (NB) is the toxicity and the poor bioavailability of traditional drugs.(#br)Methods We synthesised an amphiphilic dextrin derivative (DX‐OL) able to host fenretinide (4‐HPR) by complexat...
作者:Isabella Orienti , R. Treré ...
来源:[J].Archiv der Pharmazie(IF 1.54), 2002, Vol.335 (2鈥?), pp.89-93Wiley
摘要:Abstract(#br)Poly(vinyl alcohol) was crosslinked with ethylene glycol diglycidyl ether to obtain hydrogel‐forming polymers. The polymers were also substituted with oleoyl chloride, providing hydrogels with weak solubility.These new polymeric materials were evaluated for the ...
作者:Isabella Orienti , Giovanna Gentilomi ...
来源:[J].Archiv der Pharmazie(IF 1.54), 1998, Vol.331 (11), pp.347-351Wiley
摘要:Abstract(#br)Poly(methyl vinyl ether‐alt‐maleic anhydride) substituted with cholamine (CA), aminoethylcholamine (AECA), or aminooctyl‐cholamine (AOCA) at different substitution degrees, were used for methotrexate (MTX) complexation. The solid complexes, isolated by prec...
作者:Isabella Orienti , Anna Di Pietra ...
来源:[J].Archiv der Pharmazie(IF 1.54), 2000, Vol.333 (12), pp.421-424Wiley
摘要:Abstract(#br)Polyvinylalcohol crosslinked with succinyl, adipoyl, or sebacoyl chloride at two different degrees of crosslinking was prepared and employed as a supporting material for aqueous topical gels containing propranolol hydrochloride, which was chosen as a hydrophilic mode...

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