全部文献期刊学位论文会议报纸专利标准年鉴图书|学者科研项目
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作者:Irving J. Bigio , Robert M. Straubinger
来源:[J].Journal of Neuro-Oncology(IF 3.115), 2017, Vol.133 (1), pp.77-85Springer
摘要:The cell-penetrating trans-activator of transcription (TAT) is a cationic peptide derived from human immunodeficiency virus-1. It has been used to facilitate macromolecule delivery to various cell types. This cationic peptide is capable of crossing the blood–brain barrier an...
作者:... Michael J. O’Brien , Irving J. Bigio , Satish K. Singh
来源:[J].Gastrointestinal Endoscopy(IF 5.21), 2015, Vol.81 (3), pp.539-547Elsevier
摘要:Background(#br)Elastic-scattering spectroscopy (ESS) can assess in vivo and in real-time the scattering and absorption properties of tissue related to underlying pathologies.(#br)Objectives(#br)To evaluate the potential of ESS for differentiating neoplastic from non-neoplastic po...
作者:Irving J. Bigio , Laurence B. Lovat
来源:[J].Gastrointestinal Endoscopy(IF 5.21), 2005, Vol.63 (2), pp.257-261Elsevier
摘要:Background(#br)Biopsy and polypectomy frequently are performed for lesions that carry a low risk of malignant transformation in the colon. Elastic scattering spectroscopy (ESS) is a novel optical biopsy technique that can distinguish, almost instantaneously, between normal a...
作者:... Helen Francis , Irving J. Bigio , Stephen G. Bown
来源:[J].Gastrointestinal Endoscopy(IF 5.21), 2000, Vol.51 (4), pp.AB227-AB227Elsevier
摘要:Background: Barrett's esophagus develops through dysplasia into adenocarcinoma. Surveillance for dysplasia using conventional white light endoscopy requires histological examination of multiple random biopsies, and has a poor diagnostic yield. Recently, fluorescence endoscopy has...
作者:... Jeffrey N. Bruce , Irving J. Bigio , Avraham Mayevsky
来源:[J].Brain Research(IF 2.879), 2014, Vol.1549, pp.42-51Elsevier
摘要:Abstract(#br)Disruption of blood brain barrier (BBB) is used to enhance chemotherapeutic drug delivery. The purpose of this study was to understand the time course of hemodynamic and metabolic response to intraarterial (IA) mannitol infusions in order to optimize the delivery of ...
作者:... Jeffrey N. Bruce , Irving J. Bigio , Robert M. Straubinger
来源:[J].Journal of Neuro-Oncology(IF 3.115), 2014, Vol.120 (3), pp.489-497Springer
摘要:Abstract(#br)Rapid first pass uptake of drugs is necessary to increase tissue deposition after intraarterial (IA) injection. Here we tested whether brain tissue deposition of a nanoparticulate liposomal carrier could be enhanced by coordinated manipulation of liposome surfac...
作者:Irving J. Bigio , Robert M. Straubinger
来源:[J].Journal of Neuro-Oncology(IF 3.115), 2016, Vol.128 (1), pp.21-28Springer
摘要:Abstract(#br)The relative abundance of anionic lipids on the surface of endothelia and on glioma cells suggests a workable strategy for selective drug delivery by utilizing cationic nanoparticles. Furthermore, the extracellular pH of gliomas is relatively acidic suggesting that t...
作者:... Charles W. Emala , Irving J. Bigio , Shailendra Joshi
来源:[J].Journal of Neuro-Oncology(IF 3.115), 2016, Vol.130 (3), pp.449-454Springer
摘要:Abstract(#br)Mitoxantrone is a highly cytotoxic antineoplastic drug, however, its poor penetration of the blood–brain barrier has limited its role in the treatment of brain cancers. We hypothesize that intra-arterial (IA) delivery of mitoxantrone may enhance its capacity for...

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