全部文献期刊学位论文会议报纸专利标准年鉴图书|学者科研项目
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作者:Iris Gehrke , Michael Hallek
来源:[J].Molecular Cytogenetics(IF 2.36), 2011, Vol.4 (1)Springer
摘要:Abstract(#br)The chromosomal translocation (11;14)(q13;q32) rearranging the locus for cyclin D1 ( CCND1 ) to that of the immunoglobulin heavy chain ( IGH ) can be found in virtually all cases of mantle cell lymphoma (MCL), while other CCND1 translocations are extremely rare. As C...
作者:Luis Mario Aguirre Palma , Iris Gehrke , Karl-Anton Kreuzer
来源:[J].Critical Reviews in Oncology / Hematology(IF 4.637), 2015, Vol.93 (3), pp.225-236Elsevier
摘要:Abstract(#br)The role of angiogenesis in haematological malignancies such as chronic lymphocytic leukaemia (CLL) is difficult to envision, because leukaemia cells are not dependent on a network of blood vessels to support basic physiological requirements. Regardless, CLL cells se...
作者:Iris Gehrke , Michael Hallek
来源:[J].Journal of Cancer Research and Clinical Oncology(IF 2.914), 2014, Vol.140 (8), pp.1283-1293Springer
摘要:Abstract(#br) Background(#br)The ontogenetic Wnt pathway shows almost no activity in adult tissues. In contrast, chronic lymphocytic leukemia (CLL) cells show constitutionally active Wnt signaling, which is associated with upregulated levels of pathway members such as Wnt3 a...
作者:Iris Gehrke , Rajesh Kumar Gandhirajan , Karl-Anton Kreuzer
来源:[J].European Journal of Cancer(IF 5.061), 2009, Vol.45 (16), pp.2759-2767Elsevier
摘要:Abstract(#br)Among aberrantly regulated signalling pathways in cancer the WNT/β-catenin pathway plays an outstanding role, since it was shown to be critically involved in a wide range of neoplasias. While the underlying mechanisms vary, overexpression of WNT s was found to m...
作者:Iris Gehrke , Michael Hallek
来源:[J].Leukemia Research(IF 2.764), 2011, Vol.35 (10), pp.1360-1366Elsevier
摘要:Abstract(#br)Flow cytometry is commonly used to establish the diagnosis of chronic lymphocytic leukemia (CLL). A defined combination of antibodies discriminates between normal B cells and CLL cells (coexpression of CD5, CD19, and CD23). The receptor tyrosine-like orphan receptor ...
作者:Iris Gehrke , Shauna Loewen ...
来源:[J].Archivum Immunologiae et Therapiae Experimentalis(IF 2.378), 2006, Vol.54 (2), pp.85-101Springer
摘要:Abstract.(#br)Gene amplification, over-expression, and mutation of growth factors, or the receptors themselves, causes increased signaling through receptor kinases, which has been implicated in many human cancers and is associated with poor prognosis. Tumor growth has been s...
作者:Iris Gehrke , Simon Jonas Poll‐Wolbeck
来源:[J].European Journal of Haematology(IF 2.548), 2012, Vol.89 (5), pp.373-384Wiley
摘要:Abstract(#br)There exists increasing evidence that apart from solid tumors, angiogenic growth factors also play important roles in the development and/or maintenance of hematolymphoid malignancies. Thus, in these cancers, angiogenesis and bone marrow microvessel density ofte...
作者:Iris Gehrke , Günther Plickert ...
来源:[J].Neoplasia, 2010, Vol.12 (4), pp.326,IN4-335,IN6Elsevier
摘要:Abstract(#br)BACKGROUND: Lymphoid enhancer factor-1 ( lef-1 ) is overexpressed in B-cell chronic lymphocytic leukemia (CLL) when compared with normal B cells and transcribes several genes implicated in the pathogenesis of CLL. We therefore hypothesize that antagonism of lef-...
作者:Iris Gehrke , Simon J. Poll‐Wolbeck
来源:[J].European Journal of Haematology(IF 2.548), 2010, Vol.85 (4), pp.309-313Wiley
摘要:Abstract(#br)Purpose: Wnt signaling was demonstrated to be activated in chronic lymphocytic leukemia (CLL). It is thought to be responsible for the extended survival of CLL cells in vivo . Dickkopf1 (DKK1) is known to antagonize Wnt signaling by direct high‐affinity binding ...

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