全部文献期刊学位论文会议报纸专利标准年鉴图书|学者科研项目
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作者:Irene Cherni , Baffour Awuah ...
来源:[J].BMC Medical Genomics(IF 3.466), 2017, Vol.10 (1)Springer
摘要:Significant clinical and research applications are driving large scale adoption of individualized tumor sequencing in cancer in order to identify tumors-specific mutations. When a matched germline sample is available, somatic mutations may be identified using comparative callers....
作者:Irene Cherni , Lara M. Gross ...
来源:[J].BMC Cancer(IF 3.333), 2017, Vol.17 (1)Springer
摘要:Primary cardiac angiosarcomas are rare, but they are the most aggressive type of primary cardiac neoplasms. When patients do present, it is with advanced pulmonary and/or cardiac symptoms. Therefore, many times the correct diagnosis is not made at the time of initial presentation...
作者:Irene Cherni , Baffour Awuah ...
来源:[J].BMC Medical Genomics(IF 3.466), 2017, Vol.10 (1), pp.1-17DOAJ
摘要:Abstract Background Significant clinical and research applications are driving large scale adoption of individualized tumor sequencing in cancer in order to identify tumors-specific mutations. When a matched germline sample is available, somatic mutations may be identified using ...
作者:Irene Cherni , Robert N Raju ...
来源:[J].PLoS ONE(IF 3.73), 2017, Vol.7 (5)DOAJ
摘要:Olfactory neuroblastoma (ONB) is a rare cancer of the sinonasal tract with little molecular characterization. We performed whole genome sequencing (WGS) on paired normal and tumor DNA from a patient with metastatic-ONB to identify the somatic alterations that might be drivers of ...
作者:Irene Cherni , Shilpi Arora ...
来源:[J].Lung Cancer(IF 3.392), 2012, Vol.76 (2), pp.191-196Elsevier
摘要:Abstract(#br)Introduction(#br)The Hedgehog Signaling Pathway (HHSP) has been implicated in the development of multiple cancers. HHSP activation may primarily be hedgehog ligand-dependent in non-small cell lung cancer (NSCLC); while a subset may be ligand-independent. In this...
作者:Irene Cherni , Jeffrey Doran ...
来源:[J].Chemico-Biological Interactions(IF 2.967), 2005, Vol.157, pp.331-334Elsevier
摘要:Abstract(#br)Nicotiana benthamiana plants were engineered to express a codon-optimized gene encoding the human acetylcholinesterase-R (AChE) isoform. The transgenic plants expressed the protein at >0.4% of total soluble protein, and the plant-produced enzyme was purified to homog...
作者:Irene Cherni , Jeffrey P. MacKeigan
来源:[J].Translational Oncology(IF 3.393), 2011, Vol.4 (2), pp.59-70Elsevier
摘要:Tyrosine kinase inhibitors (TKIs) have been in use as cancer therapeutics for nearly a decade, and their utility in targeting specific malignancies with defined genetic lesions has proven to be remarkably effective. Recent efforts to characterize the spectrum of genetic lesions f...

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