全部文献期刊学位论文会议报纸专利标准年鉴图书|学者科研项目
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作者:Ido Laskov , Marie-Claude Beauchamp ...
来源:[J].BMC Cancer(IF 3.333), 2017, Vol.17 (1)Springer
摘要:Phosphatase and Tensin homolog (PTEN) is a tumor suppressor gene. Loss of its function is the most frequent genetic alteration in endometrioid endometrial cancers (70–80%) and high grade tumors (90%). We assessed the sensitivity of endometrial cancer cell lines to PARP inhib...
作者:Ido Laskov , Sanaa Iqbal ...
来源:[J].BMC Cancer(IF 3.333), 2015, Vol.15 (1)Springer
摘要:Abstract(#br) Background(#br)Impairment of homologous recombination (HR) is found in close to 50 % of ovarian and breast cancer. Tumors with BRCA1 mutations show increased expression of the Insulin-like growth factor type 1 receptor (IGF-1R). We previously have shown that inhibit...
作者:Ido Laskov , Sun Qiang ...
来源:[J].BMC Medicine(IF 6.679), 2015, Vol.13 (1)Springer
摘要:Abstract(#br) Background(#br)PARP inhibitors have shown promising clinical results in cancer patients carrying BRCA1/2 mutations. Their clinical efficacy could logically be influenced by PARP1 protein levels in patient tumors.(#br) Methods(#br)We screened three cohorts of pa...
作者:Ido Laskov , Zainab Amajoud ...
来源:[J].Gynecologic Oncology(IF 3.929), 2017Elsevier
摘要:Abstract(#br)Objective(#br)Pilot study to assess the value of weekly paclitaxel plus carboplatin every 3 weeks (dose dense regimen, DD) compared to the standard 3-weekly protocol in the adjuvant setting for endometrial cancer.(#br)Methods(#br)Retrospective cohort study compa...
作者:Ido Laskov , Liron Kogan ...
来源:[J].Gynecologic Oncology(IF 3.929), 2018, Vol.148 (3), pp.553-558Elsevier
摘要:Abstract(#br)Objective(#br)The expression of homologous recombination (HR) genes in high grade ovarian cancer (HGOC) samples from debulking surgeries were correlated to outcomes in patients selected for chemotherapy treatment regimens.(#br)Study design(#br)RNA was extracted ...
作者:Ido Laskov , Laura Drudi ...
来源:[J].Gynecologic Oncology(IF 3.929), 2014, Vol.134 (3), pp.607-614Elsevier
摘要:Abstract(#br)Background(#br)Metformin has been associated with reduced cancer risk. The mechanisms underlying this cancer protective effect remain unknown.(#br)Methods(#br)“Window of opportunity” study of metformin in women with operable endometrial cancer (EC). Eleven newly...
作者:Ido Laskov , Jeremie Abitbol ...
来源:[J].Gynecologic Oncology(IF 3.929), 2016Elsevier
摘要:Abstract(#br)Objective(#br)To evaluate clinical outcome in patients selected to receive neoadjuvant chemotherapy (NACT) compared to primary debulking surgery (PDS).(#br)Methods(#br)Retrospective study including all consecutive patients diagnosed and treated for advanced (sta...
作者:Ido Laskov , Sharon Maslovitz ...
来源:[J].International Journal of Gynecology and Obstetrics(IF 1.836), 2013, Vol.123 (3), pp.200-202Elsevier
摘要:Abstract(#br)Objective(#br)To evaluate the significance of persistent lower abdominal pain in women with previous cesarean delivery.(#br)Methods(#br)Various maternal outcomes were compared between women who underwent repeated cesareans owing to persistent lower abdominal pain (st...

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