全部文献期刊学位论文会议报纸专利标准年鉴图书|学者科研项目
中外文文献  中文文献  外文文献
作者:Ian Tomlinson , Arild Nesbakken ...
来源:[J].Genome Medicine(IF 3.397), 2017, Vol.9 (1)Springer
摘要:Approximately 15% of primary colorectal cancers have DNA mismatch repair deficiency, causing a complex genome with thousands of small mutations—the microsatellite instability (MSI) phenotype. We investigated molecular heterogeneity and tumor immunogenicity in relation to cli...
作者:Ian Tomlinson , Richard Mott
来源:[J].BMC Genetics(IF 2.808), 2016, Vol.17 (1)Springer
摘要:Abstract(#br) Background(#br)Colorectal cancer is an abnormal tissue development in the colon or rectum. Most of CRCs develop due to somatic mutations, while only a small proportion is caused by inherited mutations. Familial adenomatous polyposis is an inherited genetic disease, ...
作者:... Generoso Bevilacqua , Ian Tomlinson , Stefania Segditsas
来源:[J].PLoS ONE(IF 3.73), 2010, Vol.5 (11)DOAJ
摘要:We have previously shown that serum/glucocorticoid regulated kinase 1 (SGK1) is down-regulated in colorectal cancers (CRC) with respect to normal tissue. As hyper-methylation of promoter regions is a well-known mechanism of gene silencing in cancer, we tested whether the SGK1 pro...
作者:John M. Findlay , Mark R. Middleton , Ian Tomlinson
来源:[J].Digestive Diseases and Sciences(IF 2.26), 2016, Vol.61 (1), pp.25-38Springer
摘要:Abstract(#br)Barrett’s esophagus (BE) is a common and important precursor lesion of esophageal adenocarcinoma (EAC). A third of patients with BE are asymptomatic, and our ability to predict the risk of progression of metaplasia to dysplasia and EAC (and therefore guide manag...

我们正在为您处理中,这可能需要一些时间,请稍等。

资源合作:cnki.scholar@cnki.net, +86-10-82896619   意见反馈:scholar@cnki.net

×