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作者:... Woo Suk Hwang , Sang-Hwan Hyun , Hyunggee Kim
来源:[J].Biological Procedures Online(IF 0.95), 2017, Vol.19 (1)
摘要:Somatic cell nuclear transfer (SCNT) is a useful biotechnological tool for transgenic animal production using genetically modified somatic cells (GMSCs). However, there are several limitations preventing successful transgenic animal generation by SCNT, such as obtaining proper so...
作者:Jung Yun Kim , Jun-Kyum Kim , Hyunggee Kim
来源:[J].Oncogene(IF 7.357), 2020, Vol.39 (9), pp.1969-1982
摘要:Abstract(#br)Most of the mechanisms governing apoptotic and non-apoptotic cell death are regulated independently. However, cells may experience various stresses that lead to both apoptotic and non-apoptotic cell death. In particular, cancer cells require a program that simultaneo...
作者:... Sung-Hak Kim , Xun Jin , Hyunggee Kim
来源:[J].Biochemical and Biophysical Research Communications(IF 2.406), 2018, Vol.496 (4), pp.1013-1018
摘要:Abstract(#br)Glioma stem-like cells (GSCs) contribute to tumor initiation, progression, and therapeutic resistance, but their cellular origin remains largely unknown. Here, using a stem/progenitor cell-fate tracking reporter system in which eGFP is expressed by promoter of OCT4 t...
作者:... Xiong Jin , Sung-Chan Kim , Hyunggee Kim
来源:[J].Biochemical and Biophysical Research Communications(IF 2.406), 2017, Vol.486 (2), pp.564-570
摘要:Abstract(#br)Most cancer-related signaling pathways sustain their active or inactive status via genetic mutations or various regulatory mechanisms. Previously, we demonstrated that platelet-derived growth factor (PDGF) activates Notch signaling through nitric oxide (NO)-sign...
作者:Hyunggee Kim , Yun-Hee Kim ...
来源:[J].Cancer Letters(IF 4.258), 2018, Vol.414, pp.181-189
摘要:Abstract(#br)Despite expressing high levels of the epidermal growth factor receptor (EGFR), a majority of oral squamous cell carcinoma (OSCC) patients show limited response to cetuximab and ultimately develop drug resistance. However, mechanism underlying cetuximab resistance in ...
作者:... Nayoung Hong , Yong Yook Lee , Hyunggee Kim
来源:[J].Journal of Ethnopharmacology(IF 2.755), 2019, Vol.236, pp.393-400
摘要:Abstract(#br)Ethnopharmacological relevance(#br)Korean Red ginseng extract (RG) is one of the most widely used traditional health functional food in Asia, which invigorates immunity and vital energy. RG have been suggested to inhibit proliferation, invasion, and inflammation...
作者:... Ja Yun Lim , Hyunggee Kim , Seung-Ki Kim
来源:[J].PLoS ONE(IF 3.73), 2017, Vol.10 (6)
摘要:In neuro-oncology, the biology of neural stem cells (NSCs) has been pursued in two ways: as tumor-initiating cells (TICs) and as a potential cell-based vehicle for gene therapy. NSCs as well as mesenchymal stem cells (MSCs) have been reported to possess tumor tropism capacities. ...
作者:Hyunggee Kim , Eui-Bae Jeung ...
来源:[J].Theriogenology(IF 2.082), 2016, Vol.85 (4), pp.601-616
摘要:Abstract(#br)The establishment of porcine embryonic stem cells (ESCs) would have great impact in biomedical studies and preclinical trials through their use in genetic engineering. However, authentic porcine ESCs have not been established until now. In this study, a total of seve...
作者:Hyunggee Kim , Eui-bae Jeung
来源:[J].Theriogenology(IF 2.082), 2015, Vol.84 (7), pp.1075-1087
摘要:Abstract(#br)Granulocyte colony-stimulating factor (G-CSF) is required for proliferation, differentiation, and survival of cells. It is also a biomarker of human oocyte developmental competence for embryo implantation. In humans, the G-CSF concentration peaks during the ovul...
作者:... Yunsheng Xu , Jeremy N. Rich , Hyunggee Kim
来源:[J].Cell Reports, 2016, Vol.16 (6), pp.1629-1641
摘要:Summary(#br)Inhibitor of differentiation 1 (ID1) is highly expressed in glioblastoma stem cells (GSCs). However, the regulatory mechanism responsible for its role in GSCs is poorly understood. Here, we report that ID1 activates GSC proliferation, self-renewal, and tumorigeni...

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