全部文献期刊会议图书|学者科研项目
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作者:... Xuejun Wang , Jinbao Liu , Hongbiao Huang
来源:[J].European Journal of Pharmacology(IF 2.592), 2019, Vol.846Elsevier
摘要:Abstract(#br)Auranofin (Aur) inhibits thioredoxin reductases and is also an inhibitor of 19 S proteasome associated deubiquitinases, targeting USP14 and UCHL5. Androgen receptor is often over-expressed in prostate cancer (PCa) and is strongly linked to PCa growth and progression....
作者:... Q. Ping Dou , Jinbao Liu , Hongbiao Huang
来源:[J].Cancer Letters(IF 4.258), 2019, Vol.465, pp.118-128Elsevier
摘要:Abstract(#br)Breast cancer is the most common malignancy in women around the world. Estrogen receptor α (ERα) is expressed in approximately 70% of breast tumors, and considered as one of most effective targets in breast cancer therapy. It has been reported that the degradati...
作者:Hongbiao Huang , Di Chen ...
来源:[J].Cancer Letters(IF 4.258), 2010, Vol.301 (2), pp.221-228Elsevier
摘要:Abstract(#br)Proteasome inhibition has emerged as a novel approach to anticancer therapy. Numerous natural compounds, such as gambogic acid, have been tested in vitro and in vivo as anticancer agents for cancer prevention and therapy. However, whether gambogic acid has chemosensi...
作者:... Jianqiang Zhu , Hongbiao Huang , Zhigang Liu
来源:[J].Optics and Laser Technology(IF 1.365), 2013, Vol.47, pp.189-193Elsevier
摘要:Abstract(#br)Optimized convective heat transfer is applied to accelerate the thermal recovery of a large aperture multi-segment amplifier. The paper proposes a novel project of changing the structural parameters of the inlet jet to the Nd:glass slab in the multi-segment amplifier...
作者:Hongbiao Huang , Shouting Liu ...
来源:[J].Toxicology in Vitro(IF 2.65), 2014, Vol.28 (3), pp.419-425Elsevier
摘要:Abstract(#br)Verapamil (Ver), an inhibitor of the multidrug resistance gene product, has been proved to be a promising combination partner with other anti-cancer agents including proteasome inhibitor bortezomib. Gambogic acid (GA) has been approved for Phase II clinical trials in...
作者:Hongbiao Huang , Ningning Liu ...
来源:[J].Cell Reports, 2013, Vol.3 (1), pp.211-222Elsevier
摘要:Summary(#br)Gambogic acid (GA) is a natural compound derived from Chinese herbs that has been approved by the Chinese Food and Drug Administration for clinical trials in cancer patients; however, its molecular targets have not been thoroughly studied. Here, we report that GA inhi...
作者:... Liunian Zheng , Hongbiao Huang , Jianqiang Zhu
来源:[J].High Power Laser Science and Engineering, 2013, Vol.1 (1), pp.29-35Cambridge U Press
摘要:Abstract Beam positioning stability in a laser-driven inertial confinement fusion (ICF) facility is a vital problem that needs to be fixed. Each laser beam in the facility is transmitted in lots of optics for hundreds of meters, and then targeted in a micro-sized pellet to realiz...
作者:Hongbiao Huang , Yuning Liao ...
来源:[J].Cancer Cell & Microenvironment, 2016, Vol.3 (1)智慧科学与技术公司
摘要:The deubiquitinases (DUBs) are emerging targets for cancer therapy. An increasing number of DUB inhibitors were discovered to be potential anti-tumor agents. We recently identified that auranofin (Aur), a gold-containing compound used clinically to treat rheumatoid arthritis, is ...

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