全部文献期刊学位论文会议报纸专利标准年鉴图书|学者科研项目
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作者:... Peter Schraml , Holger Moch , Niko Beerenwinkel
来源:[J].BMC Bioinformatics(IF 3.024), 2017, Vol.18 (1)Springer
摘要:Next-generation sequencing of matched tumor and normal biopsy pairs has become a technology of paramount importance for precision cancer treatment. Sequencing costs have dropped tremendously, allowing the sequencing of the whole exome of tumors for just a fraction of the total tr...
作者:Holger Moch , Aurelia Noske
来源:[J].BMC Cancer(IF 3.333), 2017, Vol.17 (1)Springer
摘要:BRCA1/2-deficient ovarian carcinomas are recognized as target for Poly (ADP-ribose) polymerase (PARP) inhibitors. BRCA1 and BRCA2 proteins are involved in homologous recombination repair of double-strand DNA breaks. The relevance of other homologous recombination repair proteins,...
作者:Holger Moch , Markus Rechsteiner ...
来源:[J].BMC Cancer(IF 3.333), 2017, Vol.17 (1)Springer
摘要:Endometrioid adenocarcinoma of the uterus and ovarian endometrioid carcinoma share many morphological and molecular features. Differentiation between simultaneous primary carcinomas and ovarian metastases of an endometrial cancer may be very challenging but is essential for progn...
作者:... David Holzmann , Holger Moch , Kristian Ikenberg
来源:[J].European Archives of Oto-Rhino-Laryngology(IF 1.458), 2017, Vol.274 (9), pp.3503-3512Springer
摘要:The aim of this study was to analyze the role of Ki-67, p53, and the “aberrant p53 pattern” in squamous cell carcinomas of the nasal vestibule. Patients between 1995 and 2014 were included. Baseline characteristics and outcome were analyzed with respect to immunohistochemica...
作者:... Mark A Rubin , Holger Moch , Peter Schraml
来源:[J].BMC Genomics(IF 4.397), 2015, Vol.16 (1)Springer
摘要:Abstract(#br) Background(#br)Chimeric read-through RNAs are transcripts originating from two directly adjacent genes (<10 kb) on the same DNA strand. Although they are found in next-generation whole transcriptome sequencing (RNA-Seq) data on a regular basis, investigating them fu...
作者:... Manuela Schmidinger , Holger Moch , Peter Schraml
来源:[J].BMC Cancer(IF 3.333), 2016, Vol.16 (1)Springer
摘要:Abstract(#br) Background(#br)The VHL protein (pVHL) is a multiadaptor protein that interacts with more than 30 different binding partners involved in many oncogenic processes. About 70 % of clear cell renal cell carcinoma (ccRCC) have VHL mutations with varying impact on pVH...
作者:... Wolfram Jochum , Holger Moch , Sandro J Stoeckli
来源:[J].BMC Cancer(IF 3.333), 2011, Vol.11 (1)Springer
摘要:Abstract(#br) Background(#br)Prognostic factors in predicting occult lymph node metastasis in patients with head and neck squamous-cell carcinoma (HNSCC) are necessary to improve the results of the sentinel lymph node procedure in this tumour type. The E-Cadherin glycoprotein is ...
作者:Holger Moch , Karsten Henco
来源:[J].PLoS ONE(IF 3.73), 2017, Vol.11 (8)DOAJ
摘要:Despite the individually different molecular alterations in tumors, the malignancy associated biological traits are strikingly similar. Results of a previous study using renal cell carcinoma (RCC) as a model pointed towards cancer-related features, which could be visualized as th...
作者:Holger Moch , Michael Wegner ...
来源:[J].PLoS Genetics(IF 8.694), 2015, Vol.11 (1)DOAJ
摘要:Melanoma is the most fatal skin cancer, but the etiology of this devastating disease is still poorly understood. Recently, the transcription factor Sox10 has been shown to promote both melanoma initiation and progression. Reducing SOX10 expression levels in human melanoma cells a...

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