全部文献期刊会议图书|学者科研项目
中外文文献  中文文献  外文文献
作者:... Sungmin Cho , Ho Jeong Kwon , Peter Karuso
来源:[J].Proteome Science(IF 2.42), 2016, Vol.15 (1)
摘要:Daptomycin is a recently introduced, last-resort antibiotic that displays a unique mode of action against Gram-positive bacteria that is not fully understood. Several bacterial targets have been proposed but no human binding partner is known.
作者:... Junik Son , Ho Jeong Kwon , Jong-Soon Choi
来源:[J].Journal of Ginseng Research(IF 2.259), 2020, Vol.44 (1), pp.50-57
摘要:Abstract(#br)Background(#br)The cellular senescence of primary cultured cells is an irreversible process characterized by growth arrest. Restoration of senescence by ginsenosides has not been explored so far. Rg3( S ) treatment markedly decreased senescence-associated β-gala...
作者:... Wankyu Kim , Jong-Won Oh , Ho Jeong Kwon
来源:[J].Scientific Reports(IF 2.927), 2020, Vol.10 (7), pp.1145-1159
摘要:Abstract(#br)Ubiquinol-cytochrome c reductase (UQCRB), a subunit of the mitochondrial complex III, is highly expressed in tissues from colorectal cancer patients. Since UQCRB is highly expressed in colorectal cancer, we investigated miRNAs from mutant UQCRB-expressing cell lines ...
作者:Chih-na Yen , Yoon Sun Cho , Ho Jeong Kwon
来源:[J].Biochemical and Biophysical Research Communications(IF 2.406), 2017, Vol.485 (2), pp.349-354
摘要:Abstract(#br)The present research reports a novel biological activity of indatraline, a compound clinically used as an antidepressant. We previously identified indatraline as an autophagy inducer. Autophagy is an intracellular catabolic pathway for degrading or recycling unn...
作者:Ho Jeong Kwon , Seong Hwan Kim
来源:[J].Bioorganic & Medicinal Chemistry Letters(IF 2.338), 2019, Vol.29 (11), pp.1350-1356
摘要:Abstract(#br)A pyrrolo[1,2- a ]pyrazine-based chemical territory was expanded via construction of new chemical library with distinctive substitution patterns, which was made possible by regiodivergent electrophilic acylation followed by aldol condensation. Biological screening of...
作者:... Yoon Sun Cho , Hukeun Lee , Ho Jeong Kwon
来源:[J].PLoS ONE(IF 3.73), 2017, Vol.9 (3)
摘要:Autophagy and apoptosis are important processes that control cellular homeostasis and have been highlighted as promising targets for novel cancer therapies. Here, we identified convallatoxin (CNT), isolated from Antiaris toxicaria, as a dual inducer of autophagy and apoptosis. CN...
作者:... Hye Jin Jung , Deepak Bhattarai , Ho Jeong Kwon
来源:[J].Biochemical and Biophysical Research Communications(IF 2.406), 2015, Vol.458 (1), pp.14-20
摘要:Abstract(#br)Hypoxia inducible factor-1 alpha (HIF-1α) plays an important role in angiogenesis and metastasis and is a promising therapeutic target for the development of anti-cancer drugs. We recently developed a new synthetic small molecule inhibitor of HIF-1α, LW6, which ...
作者:... Seung-Woo Cho , Sang-Kyou Lee , Ho Jeong Kwon
来源:[J].Cancer Letters(IF 4.258), 2015, Vol.366 (1), pp.52-60
摘要:Abstract(#br)Ubiquinol–cytochrome c reductase binding protein (UQCRB), a component of the mitochondrial complex III, has been recently implicated in angiogenesis. Targeting mitochondria to balance vascular homeostasis has been widely recognized. However, the effect of UQCRB ...
作者:... Joohye Kim , Hea-Young Park Choo , Ho Jeong Kwon
来源:[J].Biochemical and Biophysical Research Communications(IF 2.406), 2016, Vol.478 (3), pp.1117-1122
摘要:Abstract(#br)5-Lipoxygenase (5-LOX) is an enzyme that converts arachidonic acid from the cell membrane into leukotriene, a signal lipid mediator. 5-LOX deficiency markedly attenuates the formation of aneurysms in knockout mice. In addition, Zileuton, a clinical drug targeting 5-L...

我们正在为您处理中,这可能需要一些时间,请稍等。

资源合作:cnki.scholar@cnki.net, +86-10-82896619   意见反馈:scholar@cnki.net

×