全部文献期刊会议图书|学者科研项目
中外文文献  中文文献  外文文献
作者:Hiroyuki Kimura , Hideo Saji
来源:[J].Bioorganic & Medicinal Chemistry(IF 2.903), 2020, Vol.28 (1)
摘要:Abstract(#br)Pancreatic ductal adenocarcinoma (PDAC) is known to be one of the most lethal cancers. Since the majority of patients are diagnosed at an advanced stage, development of a detection method for PDAC at an earlier stage of disease progression is strongly desirable....
作者:Hiroyuki Kimura , Yu Ogawa ...
来源:[J].Bioorganic & Medicinal Chemistry(IF 2.903), 2018, Vol.26 (2), pp.463-469
摘要:Abstract(#br)β-cell mass (BCM) is known to be decreased in subjects with type-2 diabetes (T2D). Quantitative analysis for BCM would be useful for understanding how T2D progresses and how BCM affects treatment efficacy and for earlier diagnosis of T2D and development of new t...
作者:Hiroyuki Kimura , Naotaka Fujita ...
来源:[J].Bioorganic & Medicinal Chemistry(IF 2.903), 2017, Vol.25 (20), pp.5772-5778
摘要:Abstract(#br)A non-invasive method of pancreatic β-cell mass measurement is needed to enhance our understanding of the pathogenesis of diabetes, facilitate the early diagnosis of this disease, and promote the development of novel therapeutics. Here, we described the synthesi...
作者:Hiroyuki Kimura , Yusuke Yagi ...
来源:[J].Drug Metabolism and Pharmacokinetics(IF 2.071), 2019, Vol.34 (5), pp.317-324
摘要:Abstract(#br)Quantitative evaluations of the functions of uptake and efflux transporters directly in vivo is desired to understand an efficient hepatobiliary transport of substrate drugs. Pitavastatin is a substrate of organic anion transporting polypeptides (OATPs) and cana...
作者:Hiroyuki Kimura , Masashi Ueda ...
来源:[J].Bioorganic & Medicinal Chemistry(IF 2.903), 2019, Vol.27 (11), pp.2245-2252
摘要:Abstract(#br)We have designed ( S )-(5-(azetidin-2-ylmethoxy)pyridine-3-yl)methyl cyclopentadienyltricarbonyl technetium carboxylate ([ 99m Tc]CPTT–A–E) with high affinity for nicotinic acetylcholine receptors (nAChRs) using (2( S )-azetidinylmethoxy)-pyridine (A-85380) as t...
作者:Hiroyuki Kimura , Saki Yamauchi ...
来源:[J].Bioorganic & Medicinal Chemistry Letters(IF 2.338), 2018
摘要:Abstract(#br)The tripeptide formyl–Met–Leu–Phe (fMLF) is a prototype of N-formylated chemotactic peptides for neutrophils owing to its ability to bind and activate the G protein-coupled formyl peptide receptor (FPR). Here, we developed an 18 F-labeled fMLF derivative ta...
作者:Hiroyuki Kimura , Hirokazu Matsuda ...
来源:[J].Bioorganic & Medicinal Chemistry(IF 2.903), 2017, Vol.25 (4), pp.1406-1412
摘要:Abstract(#br)Insulinoma is a tumor derived from pancreatic β-cells, and the resulting hyperinsulinemia leads to characteristic hypoglycemia. Recent studies have reported the frequent overexpression of glucagon-like peptide-1 receptor (GLP-1R) in human insulinomas, suggesting...
作者:Hiroyuki Kimura , Yusuke Yagi ...
来源:[J].Bioorganic & Medicinal Chemistry(IF 2.903), 2018, Vol.26 (9), pp.2291-2301
摘要:Abstract(#br)Prostate-specific membrane antigen (PSMA), which is overexpressed in malignant prostate cancer (PCa), is an ideal target for imaging and therapy of PCa. We previously reported a PSMA imaging probe, 800CW-SCE, based on succinimidyl-Cys-C(O)-Glu (SCE) for optical ...
作者:Hiroyuki Kimura , Masahiro Ono
来源:[J].Bioorganic & Medicinal Chemistry Letters(IF 2.338), 2017, Vol.27 (21), pp.4876-4880
摘要:Abstract(#br)Prostate-specific membrane antigen (PSMA), which is highly expressed in both localized and metastatic prostate cancer (PCa), is an ideal target for imaging and therapy of PCa. We previously reported radiolabeled asymmetric urea derivatives as a PSMA-targeting radiotr...
作者:Hiroyuki Kimura , Hideo Saji
来源:[J].Nuclear Medicine and Biology(IF 2.517), 2018, Vol.64-65, pp.22-27
摘要:Abstract(#br)Introduction(#br)Radiolabeled exendin derivatives have been developed to visualize and quantify pancreatic beta cells. However, there are currently no established methods for analyzing in-vivo SPECT/CT images to quantify probe accumulation in the pancreas in rod...

我们正在为您处理中,这可能需要一些时间,请稍等。

资源合作:cnki.scholar@cnki.net, +86-10-82896619   意见反馈:scholar@cnki.net

×