全部文献期刊学位论文会议报纸专利标准年鉴图书|学者科研项目
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作者:... Hiroshi Onimaru , Toru Ishizuka , Hiromu Yawo
来源:[J].PLoS ONE(IF 3.73), 2017, Vol.11 (5)DOAJ
摘要:Despite the strength of the Cre/loxP recombination system in animal models, its application in rats trails that in mice because of the lack of relevant reporter strains. Here, we generated a floxed STOP tdTomato rat that conditionally expresses a red fluorescent protein variant (...
作者:... Takaaki Mishima , Hideki Kandori , Hiromu Yawo
来源:[J].PLoS ONE(IF 3.73), 2017, Vol.11 (11)DOAJ
摘要:With the progress of optogenetics, the activities of genetically identified neurons can be optically silenced to determine whether the neurons in question are necessary for the network performance of the behavioral expression. This logical induction is expected to be improved by ...
作者:... Ryuichi Shigemoto , Hiromu Yawo , Makoto Tamai
来源:[J].PLoS ONE(IF 3.73), 2017, Vol.4 (11)DOAJ
摘要:Channelrhodopsin-2 (ChR2), one of the archea-type rhodopsins from green algae, is a potentially useful optogenetic tool for restoring vision in patients with photoreceptor degeneration, such as retinitis pigmentosa. If the ChR2 gene is transferred to retinal ganglion cells (RGCs)...
作者:... Seiichiro Sakai , Toru Ishizuka , Hiromu Yawo
来源:[J].PLoS ONE(IF 3.73), 2017, Vol.10 (3)DOAJ
摘要:Channelrhodopsin-1 and 2 (ChR1 and ChR2) form cation channels that are gated by light through an unknown mechanism. We tested the DC-gate hypothesis that C167 and D195 are involved in the stabilization of the cation-permeable state of ChRWR/C1C2 which consists of TM1-5 of Ch...
作者:Hiromu Yawo , Ofer Yizhar
来源:[J].PLoS ONE(IF 3.73), 2017, Vol.12 (7)DOAJ
摘要:Sodium pumping rhodopsins (NaRs) are a unique member of the microbial-type I rhodopsin family which actively transport Na+ and H+ depending on ionic condition. In this study, we surveyed 12 different NaRs from various sources of eubacteria for their electrophysiological as well a...
作者:... Hajime Mushiake , Toru Ishizuka , Hiromu Yawo
来源:[J].PLoS ONE(IF 3.73), 2017, Vol.9 (4)DOAJ
摘要:The rodent whisker-barrel system has been an ideal model for studying somatosensory representations in the cortex. However, it remains a challenge to experimentally stimulate whiskers with a given pattern under spatiotemporal precision. Recently the optogenetic manipulation of ne...
作者:Hiromu Yawo , Kazuto Kobayashi ...
来源:[J].Pflügers Archiv - European Journal of Physiology(IF 4.866), 2019, Vol.471 (11-12), pp.1419-1439Springer
摘要:Abstract(#br)Paired-like homeobox gene Phox2b is predominantly expressed in pre-inspiratory neurons in the parafacial respiratory group (pFRG) in newborn rat rostral ventrolateral medulla. To analyse detailed local networks of the respiratory centre using optogenetics, the e...
作者:... Kiyoshi Ohura , Hiromu Yawo , Masaki Noda
来源:[J].Bone(IF 3.823), 2015, Vol.81, pp.306-314Elsevier
摘要:Abstract(#br)Parathyroid hormone (PTH) and 1α,25-dihydroxyvitamin D 3 (VD 3 ) are important factors in Ca 2 + homeostasis, and promote osteoclastogenesis by modulating receptor activator of nuclear factor kappa-B ligand ( RANKL ) mRNA expression. However, their contribution ...
作者:Hiromu Yawo , Yukio Komatsu
来源:[J].Sensors & Actuators: B. Chemical(IF 3.535), 2014, Vol.193, pp.660-668Elsevier
摘要:Abstract(#br)Incubation-type planar patch clamp biosensors, first described in 2008, are expected to enable the realization of high-throughput neural network screening. Several technical challenges must be overcome before this technique may be implemented. First, it is diffi...
作者:... Yuji Morimoto , Yasuhiro Nishida , Hiromu Yawo
来源:[J].Neuroscience Research(IF 2.204), 2016, Vol.112, pp.47-56Elsevier
摘要:Abstract(#br)Although noradrenaline and adrenaline are some of the most important neurotransmitters in the central nervous system, the effects of noradrenergic/adrenergic modulation on the striatum have not been determined. In order to explore the effects of adrenergic recep...

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