全部文献期刊会议图书|学者科研项目
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作者:Hiroko Ikushiro , Mami Yokota ...
来源:[J].Journal of Investigative Dermatology(IF 6.193), 2018
摘要:Abstract(#br)The innate immune element, cathelicidin antimicrobial peptide (CAMP), is vital in the formation of the antimicrobial barrier in skin. CAMP production is increased during epidermal differentiation and enriched in the stratum corneum. We recently identified an endoplas...
作者:Hiroko Ikushiro , Atsushi Nagami ...
来源:[J].Scientific Reports(IF 2.927), 2018, Vol.8 (1), pp.1-13
摘要:Abstract The biosynthesis of heme is strictly regulated, probably because of the toxic effects of excess heme and its biosynthetic precursors. In many organisms, heme biosynthesis starts with the production of 5-aminolevulinic acid (ALA from glycine and succinyl-coenzyme A, ...
作者:Hiroko Ikushiro , Hideyuki Hayashi
来源:[J].FEBS Letters(IF 3.582), 2011, Vol.585 (12), pp.1729-1734
摘要:Abstract(#br)All sphingolipid-producing organisms require the pyridoxal 5′-phosphate (PLP)-dependent serine palmitoyltransferase (SPT) to catalyse the first reaction on the de novo sphingolipid biosynthetic pathway. SPT is a member of the alpha oxoamine synthase (AOS) family...
作者:Hiroko Ikushiro , Hideyuki Hayashi , Hiroyuki Kagamiyama
来源:[J].BBA - Proteins and Proteomics(IF 3.733), 2003, Vol.1647 (1), pp.116-120
摘要:Abstract(#br)Serine palmitoyltransferase (SPT, EC 2.3.1.50) is a key enzyme in sphingolipid biosynthesis and catalyzes the decarboxylative condensation of l -serine and palmitoyl coenzyme A (CoA) to 3-ketodihydrosphingosine (KDS). We found that the gram-negative obligatory a...
作者:Hiroko Ikushiro , Hideyuki Hayashi
来源:[J].BBA - Proteins and Proteomics(IF 3.733), 2011, Vol.1814 (11), pp.1474-1480
摘要:Abstract(#br)Serine palmitoyltransferase, which is one of the α -oxamine synthase family enzymes, catalyzes the condensation reaction of L-serine and palmitoyl-CoA to form 3-ketodihydrosphingosine, the first and rate-determining step of the sphingolipid biosynthesis. As with...
作者:Hiroko Ikushiro , Yoshitaka Nakajima ...
来源:[J].BBA - Proteins and Proteomics(IF 3.733), 2003, Vol.1647 (1), pp.103-109
摘要:Abstract(#br)The notion of “ground-state destabilization” has been well documented in enzymology. It is the unfavourable interaction (strain) in the enzyme–substrate complex, and increases the k cat value without changing the k cat / K m value. During the course of the ...
作者:Hiroko Ikushiro , Hiroyuki Kagamiyama
来源:[J].BioFactors(IF 3.088), 2000, Vol.11 (1‐2), pp.97-99
摘要:Abstract(#br)Tryptophanase is catalytically more competent in alkaline pH even though the coenzyme exists as an inactive aldamine structure in this pH region. The binding of a substrate analog, 3‐indolepropionate to the enzyme shifts the equilibrium from the substituted alda...

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