全部文献期刊学位论文会议报纸专利标准年鉴图书|学者科研项目
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作者:... Łukasz Marczak , Radosław Kaźmierski , Hieronim Jakubowski
来源:[J].International Journal of Molecular Sciences(IF 2.464), 2019, Vol.20 (12)DOAJ
摘要:Ischemic stroke induces brain injury via thrombotic or embolic mechanisms involving large or small vessels. Cystathionine β-synthase deficiency (CBS), an inborn error of metabolism, is associated with vascular thromboembolism, the major cause of morbidity and mortality in af...
作者:Joanna Perła-Kaján , Hieronim Jakubowski
来源:[J].International Journal of Molecular Sciences(IF 2.464), 2019, Vol.20 (13)DOAJ
摘要:Hyperhomocysteinemia (HHcy) exerts a wide range of biological effects and is associated with a number of diseases, including cardiovascular disease, dementia, neural tube defects, and cancer. Although mechanisms of HHcy toxicity are not fully uncovered, there has been a significa...
作者:Hieronim Jakubowski , Kerstin A Wolff ...
来源:[J].PLoS Pathogens(IF 9.127), 2016, Vol.12 (10)DOAJ
摘要:The methylfolate trap, a metabolic blockage associated with anemia, neural tube defects, Alzheimer's dementia, cardiovascular diseases, and cancer, was discovered in the 1960s, linking the metabolism of folate, vitamin B12, methionine and homocysteine. However, the existence or p...
作者:Hieronim Jakubowski , Jarosław Walkowiak
来源:[J].Biomedicine & Pharmacotherapy(IF 2.068), 2018, Vol.102, pp.792-797Elsevier
摘要:Abstract(#br)Objective(#br)Garlic exerts a range of effects relevant to human health. However, its influence on the endothelium in obese individuals remains unknown. We aimed to determine the effects of garlic extract (GE) on arterial stiffness and markers of endothelial function...
作者:Kamila Borowczyk , Joanna Suliburska , Hieronim Jakubowski
来源:[J].Amino Acids(IF 3.914), 2018, Vol.50 (5), pp.537-546Springer
摘要:Abstract(#br)Growing human head hair contains a history of keratin and provides a unique model for studies of protein damage. Here, we examined mechanism of homocysteine (Hcy) accumulation and keratin damage in human hair. We found that the content of Hcy-keratin increased a...
作者:Hieronim Jakubowski
来源:[J].Analytical Biochemistry(IF 2.582), 2016, Vol.508, pp.118-123Elsevier
摘要:Abstract(#br)Homocysteine (Hcy) and its metabolites Hcy-thiolactone, N -Hcy-protein, and S -Hcy-protein are implicated in vascular and neurological diseases. However, quantification of these metabolites remains challenging. Here I describe streamlined assays for these metabo...
作者:Hieronim Jakubowski
来源:[J].Analytical Biochemistry(IF 2.582), 2016, Vol.508, pp.118-123Elsevier
摘要:Abstract(#br)Homocysteine (Hcy) and its metabolites Hcy-thiolactone, N -Hcy-protein, and S -Hcy-protein are implicated in vascular and neurological diseases. However, quantification of these metabolites remains challenging. Here I describe streamlined assays for these metabo...
作者:Hieronim Jakubowski , Leopold Eckhart ...
来源:[J].Journal of Investigative Dermatology(IF 6.193), 2019Elsevier
摘要:Abundant corneocyte surface protrusions, observed in patients with atopic dermatitis with filaggrin loss-of-function mutations, are inversely associated with levels of natural moisturizing factors (NMFs) in the stratum corneum. To dissect the etiological role of NMFs and fil...
作者:... Jaroslaw Walkowiak , Hieronim Jakubowski , Paweł Bogdański
来源:[J].Biomedical and Environmental Sciences(IF 1.154), 2016, Vol.29 (10), pp.706-712Elsevier
摘要:Abstract(#br)Objective(#br)Obesity is associated with kidney defects. Physical activity is a key element in the treatment of obesity. The aim of this study was to compare the effect of endurance and endurance-strength training on kidney function in abdominally obese women.(#br)Me...

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