全部文献期刊学位论文会议报纸专利标准年鉴图书|学者科研项目
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作者:Henk M.W. Verheul , Haiko J. Bloemendal ...
来源:[J].Clinical Genitourinary Cancer(IF 1.429), 2015, Vol.13 (4), pp.271-279Elsevier
摘要:Abstract(#br)Systemic treatment of men with metastatic prostate cancer is rapidly evolving. Androgen deprivation therapy remains the first-line treatment for advanced disease and the backbone of sequential strategies. For patients with extensive metastatic disease the addition of...
作者:Henk M.W. Verheul , Sylvie Rottey ...
来源:[J].Clinical Therapeutics(IF 2.23), 2016, Vol.38 (10), pp.2286-2299Elsevier
摘要:Abstract(#br)Purpose(#br)The metabolism of olaparib, a potent inhibitor of poly(ADP-ribose) polymerase (PARP) with demonstrated efficacy in patients with BRCA -mutated ovarian cancer, is mediated by cytochrome P450 (CYP) enzymes (predominantly CYP3A4/5). We assessed the pote...
作者:Henk M.W. Verheul , Tanja D. de Gruijl
来源:[J].Critical Reviews in Oncology / Hematology(IF 4.637), 2014, Vol.92 (3), pp.153-165Elsevier
摘要:Abstract(#br)Over the past decades advances in bioengineering and expanded insight in tumor immunology have resulted in the emergence of novel bispecific antibody (bsAb) constructs that are capable of redirecting immune effector cells to the tumor microenvironment. (Pre-) clinica...
作者:Henk M.W. Verheul , Herbert M. Pinedo
来源:[J].Clinical Breast Cancer(IF 2.422), 2000, Vol.1, pp.S80-S84Elsevier
摘要:Abstract(#br)Angiogenesis, or the formation of new blood vessels from preexisting vasculature, plays a major role in tumor growth and metastasis formation. Therefore, inhibiting tumor angiogenesis may be a promising therapeutic strategy. Paracrine stimuli from tumor cells are the...
作者:... Yasushi Ishihama , Henk M.W. Verheul , Connie R. Jimenez
来源:[J].Journal of Proteomics(IF 4.088), 2015, Vol.127, pp.247-258Elsevier
摘要:Abstract(#br)Robust phosphopeptide enrichment methods with minimal fractionation are required to profile signaling network analysis in cancer cell lines and tissues. We assessed performance of single-shot LC-MS/MS label-free phosphoproteomics using TiOx-based phosphopeptide ...
作者:Henk M.W. Verheul , Tanja D. de Gruijl
来源:[J].Clinical Immunology(IF 3.771), 2016, Vol.169, pp.128-138Elsevier
摘要:Abstract(#br)Vγ9Vδ2-T cells constitute the predominant subset of γδ-T cells in human peripheral blood and have been shown to play an important role in antimicrobial and antitumor immune responses. Several efforts have been initiated to exploit these cells for cancer immunoth...
作者:Henk M.W. Verheul , Otto S. Hoekstra
来源:[J].European Urology(IF 10.476), 2016, Vol.70 (3), pp.416-426Elsevier
摘要:Abstract(#br)Context(#br)The majority of patients with castration-resistant prostate cancer develop bone metastatic disease. It is often challenging to optimally palliate malignant bone pain. In case of multifocal pain due to diffuse osteoblastic metastases, treatment with b...
作者:Henk M.W. Verheul , Anna-Karin Olsson
来源:[J].BBA - Reviews on Cancer(IF 9.033), 2015, Vol.1855 (2), pp.155-171Elsevier
摘要:Abstract(#br)Improvement of patient survival by anti-angiogenic therapy has proven limited. A vaccination approach inducing an immune response against the tumor vasculature combines the benefits of immunotherapy and anti-angiogenesis, and may overcome the limitations of current a...
作者:Henk M.W. Verheul , Tanja D. de Gruijl
来源:[J].Clinical Immunology(IF 3.771), 2015, Vol.158 (1), pp.92-99Elsevier
摘要:Abstract(#br)CD1d-restricted invariant natural killer T (iNKT) cells constitute an important immunoregulatory T cell subset that can be activated by the synthetic glycolipid α-galactosylceramide (α-GalCer) and initiate antitumor immune responses. As cancer patients are frequ...
作者:... Gerdien C. Ligthart-Melis , Martijn W. Heymans , Henk M.W. Verheul
来源:[J].Nutrition and Cancer(IF 2.695), 2012, Vol.64 (6), pp.826-832Taylor & Francis
摘要:The cutoff value of critical weight loss is still subject of discussion. In this pilot study, we investigated whether ≥5% weight loss in the past year predicts changes in nutritional status in patients with advanced cancer during treatment with palliative chemotherapy. In 20...

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