全部文献期刊会议图书|学者科研项目
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作者:... Shangfeng Gao , Rutong Yu , Hengliang Shi
来源:[J].Molecular Neurobiology(IF 5.471), 2017, Vol.54 (7), pp.5008-5016
摘要:Human glioma causes substantial morbidity and mortality worldwide. However, the molecular mechanisms underlying glioma progression are still largely unknown. COP1 (constitutively photomorphogenic 1), an E3 ubiquitin ligase, is important in cell survival, development, cell growth,...
作者:Hengliang Shi , Xuejiao Liu ...
来源:[J].Cancer Letters(IF 4.258), 2018, Vol.415, pp.151-163
摘要:Abstract(#br)The RIO (right open reading frame) protein kinases include RIOK1, RIOK2 and RIOK3. Emerging evidence has suggested an important role of RIO kinases in cancer cell proliferation, apoptosis, migration and invasion. However, the expression profile and specific roles of ...
作者:Hengliang Shi , Zhenzhen Wang ...
来源:[J].Cellular Physiology and Biochemistry(IF 3.415), 2018, Vol.50 (6), pp.2314-2328
摘要:Background/Aims: Chronic Lymphocytic leukemia (CLL) is characterized by accumulation of cells in the G0/G1 phase of the cell cycle and resistance to apoptosis due to gene mutation or abnormal gene expression. In our previous study, constitutively photomorphogenic 1 (COP1) wa...
作者:... Bin Wang , Hengliang Shi , Renhao Wang
来源:[J].Tumor Biology(IF 2.518), 2016, Vol.37 (8), pp.10375-10382
摘要:Abstract(#br)Hepatitis B virus (HBV)-associated hepatocellular carcinoma (HCC) is the most widespread type of liver cancer. However, the underlying mechanism of HCC tumorigenesis is very intricate and HBV-encoded X protein (HBx) has been reported to play a key role in this proces...
作者:Hengliang Shi , Dong Lu ...
来源:[J].Cancer Letters(IF 4.258), 2014, Vol.355 (1), pp.121-129
摘要:Abstract(#br)Protein kinase D2 (PKD2) has been demonstrated to promote tumorigenesis in many types of cancers. However, how PKD2 regulates cancer cell growth is largely unknown. In this study, we found that over-expression of PKD2 promoted glioma cell growth but down-regulation o...
作者:Hengliang Shi , Daxue Zheng ...
来源:[J].Biomaterials(IF 7.604), 2012, Vol.33 (18), pp.4589-4596
摘要:Abstract(#br)Recent studies in amphiphilic cationic polymers have demonstrated their potential as gene carriers with high transfection efficiency and low cytotoxicity in the in vitro settings to deliver drug, siRNA and plasmid DNA. Yet their safety and efficacy in vivo remain to ...
作者:... Shao Xie , Hengliang Shi , Rutong Yu
来源:[J].Oncology Reports(IF 2.297), 2017, Vol.37 (5), pp.2565-2574
摘要:Νeuronal precursor cell expressed and developmentally downregulated protein(Nedd4-1) is an E3 ubiquitin ligase with critical roles in the pathogenesis ofcancer. Herein, we demonstrated that Nedd4-1 protein was upregulated in gliomatissues vs. that in non-cancerous tissues by...
作者:... Lei Wang , Hengliang Shi , Rutong Yu
来源:[J].Journal of Neuro-Oncology(IF 3.115), 2017, Vol.131 (1), pp.31-39
摘要:Abstract(#br)Jab1 (Jun activation domain-binding protein 1), also known as CSN5 (COP9 signalosome subunit 5), is frequently overexpressed in several cancer types. However, the biological functions and the molecular mechanisms of the Jab1 protein in human gliomas have not bee...
作者:Hengliang Shi , Bao Zheng ...
来源:[J].Oncology Reports(IF 2.297), 2015, Vol.33 (3), pp.1185-1190
摘要:It has been reported that by regulating PHD3 stability, Siah1 contributesto the abundance of hypoxia-inducible factor (HIF)-1α, thereby playing an importantrole in the cellular response to hypoxia. However, the expression level and functionalsignificance of Siah1 in human ma...

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