全部文献期刊学位论文会议报纸专利标准年鉴图书|学者科研项目
中外文文献  中文文献  外文文献
作者:Helle K. Erichsen , David T. Brown ...
来源:[J].Neuropharmacology(IF 4.114), 2012, Vol.63 (8), pp.1360-1367Elsevier
摘要:Abstract(#br)GABA-A receptor positive allosteric modulators (PAMs) mediate robust analgesia in animal models of pathological pain, in part via enhancing injury-induced loss of GABA-A-α2 and -α3 receptor function within the spinal cord. As yet, a lack of clinically suitable t...
作者:Helle K. Erichsen , Morten Grunnet ...
来源:[J].European Journal of Pharmacology(IF 2.592), 2013, Vol.709 (1-3), pp.52-63Elsevier
摘要:Abstract(#br)K v 7 channel activators decrease neuronal excitability and might potentially treat neuronal hyperexcitability disorders like epilepsy and mania. Here we introduce NS15370 ((2-(3,5-difluorophenyl)- N -[6-[(4-fluorophenyl)methylamino]-2-morpholino-3-pyridyl]aceta...
作者:... Lotte Marcher , Helle K. Erichsen , Majid Sheykhzade
来源:[J].Pharmacology, Biochemistry and Behavior(IF 2.608), 2012, Vol.101 (3), pp.465-478Elsevier
摘要:Abstract(#br)Different neurobiological mechanism(s) might contribute to evoked and non-evoked pains and to limited translational drug discovery efforts. Other variables including the pain model and sensory testing method used, dose/route/preadministration time of compound(s)...
作者:Helle K. Erichsen , Mark G. Rae
来源:[J].Neuropharmacology(IF 4.114), 2011, Vol.61 (1), pp.121-132Elsevier
摘要:Abstract(#br)After injury GABA A receptor positive allosteric modulators (PAMs) mediate robust analgesia in animals via putative restoration of post-synaptic GABA A -α2 and -α3 receptor function within the spinal cord. GABA can also act at GABA A receptors localized on prima...
作者:Gordon Munro , Helle K. Erichsen , Naheed R. Mirza
来源:[J].Neuropharmacology(IF 4.114), 2007, Vol.53 (5), pp.609-618Elsevier
摘要:Abstract(#br)Signs and symptoms of persistent pain are associated with neuronal hyperexcitability within nociceptive pathways. This manifests behaviourally as a decrease in the nociceptive threshold to sensory stimulation, and is closely correlated with altered affective pai...
作者:Helle K. Erichsen , Alexander N. Nielsen ...
来源:[J].Neuropharmacology(IF 4.114), 2007, Vol.54 (2), pp.331-343Elsevier
摘要:Abstract(#br)Tramadol is an atypical analgesic with a unique dual mechanism of action. It acts on monoamine transporters to inhibit reuptake of noradrenaline (NA) and serotonin (5-HT), and consequent upon metabolism, displays potent agonist activity at μ-opioid receptors. He...
作者:Helle K. Erichsen , Tino Dyhring ...
来源:[J].CNS Neuroscience & Therapeutics(IF 4.458), 2016, Vol.22 (2), pp.135-145Wiley
摘要:Summary(#br)Aims(#br)Here, we investigate the pharmacology of NS 383, a novel small molecule inhibitor of acid‐sensing ion channels ( ASIC s).(#br)Methods(#br)ASIC inhibition by NS 383 was characterized in patch‐clamp electrophysiological studies. Analgesic properties were e...

我们正在为您处理中,这可能需要一些时间,请稍等。

资源合作:cnki.scholar@cnki.net, +86-10-82896619   意见反馈:scholar@cnki.net

×