全部文献期刊学位论文会议报纸专利标准年鉴图书|学者科研项目
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作者:Hayley Davis , Erna Raja ...
来源:[J].Cytokine and Growth Factor Reviews(IF 8.831), 2016, Vol.27, pp.81-92Elsevier
摘要:Abstract(#br)The bone morphogenetic proteins (BMPs) play fundamental roles in embryonic development and control differentiation of a diverse set of cell types. It is therefore of no surprise that the BMPs also contribute to the process of tumourigenesis and regulate cancer progre...
作者:... Susan Giblett , Hayley Davis , Catrin Pritchard
来源:[J].Cellular Signalling(IF 4.304), 2016, Vol.28 (6), pp.561-571Elsevier
摘要:Abstract(#br)The V600E BRAF oncogenic mutation is detected in a wide range of human cancers and induces hyperactivation of the downstream MEK–ERK signalling cascade. Although output of the BRAF–MEK–ERK pathway is regulated by feed-forward RAF activity, feedback control ...
作者:Hayley Davis , Ayman Al Haj Zen ...
来源:[J].The Journal of Pathology(IF 7.585), 2017, Vol.242 (2), pp.178-192Wiley
摘要:Abstract(#br)The functional role of bone morphogenetic protein ( BMP ) signalling in colorectal cancer ( CRC ) is poorly defined, with contradictory results in cancer cell line models reflecting the inherent difficulties of assessing a signalling pathway that is context‐depe...
作者:Hayley Davis , Markus E. Diefenbacher ...
来源:[J].Gastroenterology(IF 12.821), 2010, Vol.139 (3), pp.929-941Elsevier
摘要:Background & Aims(#br)The E3 ubiquitin ligase F-box and WD repeat domain-containing 7 (Fbw7) degrades several proto-oncogenes including c-Myc, cyclinE, Notch1, and c-Jun. Fbw7 is the fourth most frequently mutated gene in human colorectal carcinomas and has recently been describe...
作者:Hayley Davis , Emma Jaeger ...
来源:[J].Cell Reports, 2014, Vol.8 (4), pp.983-990Elsevier
摘要:Summary(#br)A rare germline duplication upstream of the bone morphogenetic protein antagonist GREM1 causes a Mendelian-dominant predisposition to colorectal cancer (CRC). The underlying disease mechanism is strong, ectopic GREM1 overexpression in the intestinal epithelium. H...
作者:Hayley Davis , Shazia Irshad ...
来源:[J].The Journal of Pathology(IF 7.585), 2015, Vol.237 (2), pp.135-145Wiley
摘要:Abstract(#br)The conventional model of intestinal epithelial architecture describes a unidirectional tissue organizational hierarchy with stem cells situated at the crypt base and daughter cells proliferating and terminally differentiating as they progress along the vertical...
作者:Hayley Davis , Ian Tomlinson
来源:[J].The Journal of Pathology(IF 7.585), 2012, Vol.227 (2), pp.e2-e2Wiley

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