全部文献期刊会议图书|学者科研项目
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作者:... Hong Tao , Nobuya Kurabe , Haruhiko Sugimura
来源:[J].BMC Genomics(IF 4.397), 2017, Vol.18 (1)Springer
摘要:Human endogenous retroviruses (HERVs) belong to the LTR-retrotransposon family, where the complete HERV sequence contains two long terminal repeats (LTRs) located at each end. Intact LTRs possess highly conserved transcriptional promoter and enhancer sequences, so analyses of HER...
作者:Haruhiko Sugimura , Takamitsu Sasaki ...
来源:[J].Drug Metabolism and Pharmacokinetics(IF 2.071), 2015, Vol.30 (4), pp.263-268Elsevier
摘要:Abstract(#br)Cytochrome P450 2A6 (CYP2A6) is an enzyme involved in the metabolism of tobacco carcinogens, which are important risk factors in lung cancer. We and others have previously reported that CYP2A6*4 , a whole-gene deletion polymorphism, is associated with lower risk...
作者:... Makiko Morita , Suminori Kono , Haruhiko Sugimura
来源:[J].Oxidative Medicine and Cellular Longevity(IF 3.393), 2014, Vol.2014DOAJ
摘要:Purpose. The biallelic inactivation of the 8-hydroxyguanine repair gene MUTYH leads to MUTYH-associated polyposis (MAP), which is characterized by colorectal multiple polyps and carcinoma(s). However, only limited information regarding MAP in the Japanese population is presently ...
作者:Haruhiko Sugimura , Masakazu Hayashida
来源:[J].Journal of Pharmacological Sciences(IF 2.15), 2014, Vol.126 (3), pp.253-263DOAJ
摘要:Abstract.: G-protein–activated inwardly rectifying potassium (GIRK) channels are expressed in many tissues and activated by several Gi/o protein–coupled receptors, such as opioid and dopamine receptors, and thus are known to be involved in the modulation of opioid-induced an...
作者:Haruhiko Sugimura , Yoichi Matsubara ...
来源:[J].Drug Metabolism and Pharmacokinetics(IF 2.071), 2011, Vol.26 (5), pp.544-547Elsevier
摘要:Summary:(#br)Cytochrome P450 2A13 (CYP2A13) is a human CYP enzyme that is selectively expressed in the respiratory tract. It plays an active role in the metabolic activation of a tobacco-specific procarcinogen. In this study, the entire coding sequence and the exon-intron junctio...
作者:Haruhiko Sugimura , Takamitsu Sasaki ...
来源:[J].Drug Metabolism and Pharmacokinetics(IF 2.071), 2011, Vol.26 (5), pp.516-522Elsevier
摘要:Summary:(#br)Genetic polymorphisms of enzymes involved in the metabolism of carcinogens are suggested to modify an individual’s susceptibility to lung cancer. The purpose of this study was to investigate the relationship between lung cancer cases in Japan and variant alleles...
作者:Haruhiko Sugimura , Hironori Haga ...
来源:[J].Gastric Cancer(IF 3.989), 2019, Vol.22 (4), pp.892-898Springer
摘要:Abstract(#br)Germline mutations in CDH1 , encoding E-cadherin, are known to be the causative mechanism of hereditary diffuse gastric cancer (HDGC). We encountered two cases of gastric cancer in a Japanese family with HDGC. A 28-year-old man (Case 1) died of advanced gastric cance...
作者:... Kazuya Shinmura , Toshihiro Tsuneyoshi , Haruhiko Sugimura
来源:[J].Journal of Genetics(IF 0.876), 2005, Vol.84 (2), pp.131-136Springer
摘要:Abstract(#br)Genetic polymorphisms associated with structural changes of their gene product are important in terms of their potential relation with diseases. Therefore, in this study, splice-site variants of the transmembrane serine protease gene TMPRSS4 , nephronophthisis gene N...

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