全部文献期刊学位论文会议报纸专利标准年鉴图书|学者科研项目
中外文文献  中文文献  外文文献
作者:Hariprasad Vankayalapati , Allan R Goldberg
来源:[J].PLoS ONE(IF 3.73), 2017, Vol.8 (4)DOAJ
摘要:We identified an essential cell wall biosynthetic enzyme in Bacillus anthracis and an inhibitor thereof to which the organism did not spontaneously evolve measurable resistance. This work is based on the exquisite binding specificity of bacteriophage-encoded cell wall-hydrolytic ...
作者:... Matthew Might , Hariprasad Vankayalapati , Balagurunathan Kuberan
来源:[J].Bioorganic & Medicinal Chemistry Letters(IF 2.338), 2017Elsevier
摘要:Abstract(#br)N -Glycanase deficiency, or NGLY1 deficiency, is an extremely rare human genetic disease. N -Glycanase, encoded by the gene NGLY1 , is an important enzyme involved in protein deglycosylation of misfolded proteins. Deglycosylation of misfolded proteins precedes t...
作者:... Sunil Sharma , David J. Bearss , Hariprasad Vankayalapati
来源:[J].Bioorganic & Medicinal Chemistry Letters(IF 2.338), 2017, Vol.27 (24), pp.5473-5480Elsevier
摘要:Abstract(#br)In this work, we describe the use of the rule of 3 fragment-based strategies from biochemical screening data of 1100 in-house, small, low molecular weight fragments. The sequential combination of in silico fragment hopping and fragment linking based on S160/Y161/A162...
作者:Hariprasad Vankayalapati , Mamoru Koketsu
来源:[J].Bioorganic & Medicinal Chemistry Letters(IF 2.338), 2017, Vol.27 (22), pp.5027-5030Elsevier
摘要:Abstract(#br)Xylosides are small molecules that serve as primers of glycosaminoglycan biosynthesis. Xyloside mediated modulation of biological functions depends on the extent of priming activity and fine structures of primed GAG chains. In earlier studies, copper (Cu) cataly...
作者:Hariprasad Vankayalapati , Sherrie L. Perkins ...
来源:[J].Blood Cells, Molecules and Diseases(IF 2.259), 2012, Vol.49 (3-4), pp.152-158Elsevier
摘要:Abstract(#br)Background(#br)Glucose-6-phosphate dehydrogenase (G6PD) deficiency, affecting more than 500 million people worldwide, is one of the most common of inherited disorders. There are 186 G6PD mutations published, with mutational clustering within defined ethnic/racia...
作者:Hariprasad Vankayalapati , Zhengping Zhuang ...
来源:[J].Journal of Molecular Medicine(IF 4.768), 2013, Vol.91 (4), pp.507-512Springer
摘要:Abstract(#br)Congenital polycythemias have diverse etiologies, including mutations in the hypoxia sensing pathway. These include HIF2A at exon 12, VHL gene (Chuvash polycythemia), and PHD2 mutations, which in one family was also associated with recurrent pheochromocytoma/paragang...
作者:Hariprasad Vankayalapati , Gurdial Singh
来源:[J].Tetrahedron Letters(IF 2.397), 1999, Vol.40 (20), pp.3925-3928Elsevier
摘要:Abstract(#br)Activation of the anomeric centre of suitably protected l -fucopyranose and d -galactopyranose with propane-1,3-diyl phosphate allowed the synthesis of the disaccharide α- l -Fuc p -(1,2)-β- d -Gal p (1)-4-methylumbelliferone as a fucosidase substrate.
作者:Hariprasad Vankayalapati , Gurdial Singh , Isabelle Tranoy
来源:[J].Tetrahedron: Asymmetry(IF 2.115), 2001, Vol.12 (9), pp.1373-1381Elsevier
摘要:Abstract(#br)Glycosyl donors having a diphenylphosphinate and a propane-1,3-diyl phosphate leaving group were easily prepared by the addition of the anomeric hydroxyl group of 2,3,4,6-tetra- O -benzyl-α,β- d -glucopyranose to diphenylphosphinic and propane-1,3-diyldioxyphosp...
作者:Hariprasad Vankayalapati , Roberto Nussenzveig ...
来源:[J].Experimental Hematology(IF 2.907), 2010, Vol.39 (1), pp.14-25Elsevier
摘要:Objective(#br)Constitutive activation of the Janus kinase 2 (JAK2) due to a somatic mutation ( JAK2 V617F ) arising in hematopoietic stem cells plays a central role in the pathophysiology of myeloproliferative neoplasms (MPNs). To investigate the hypothesis that drugs that i...

我们正在为您处理中,这可能需要一些时间,请稍等。

资源合作:cnki.scholar@cnki.net, +86-10-82896619   意见反馈:scholar@cnki.net

×