全部文献期刊会议图书|学者科研项目
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作者:... Thorsten Book , Harald Mischak , Michael P. Manns
来源:[J].Journal of Biomedical Science, 2020, Vol.27 (1), pp.1503-1510
摘要:Abstract(#br)Background(#br)Detection of cholangiocarcinoma (CCA) remains a diagnostic challenge. We established diagnostic peptide biomarkers in bile and urine based on capillary electrophoresis coupled to mass spectrometry (CE-MS) to detect both local and systemic changes durin...
作者:Harald Mischak , Jan A. Staessen ...
来源:[J].Critical Care, 2020, Vol.24 (29), pp.849-856
摘要:Abstract(#br)Rationale(#br)The urinary proteome reflects molecular drivers of disease. Objectives(#br)To construct a urinary proteomic biomarker predicting 1-year post-ICU mortality. Methods(#br)In 1243 patients, the urinary proteome was measured on ICU admission, using capi...
作者:Harald Mischak , Angel Argiles ...
来源:[J].Scientific Reports(IF 2.927), 2020, Vol.10 (A7), pp.e0158765-409
摘要:Abstract(#br)Current diagnostic measures for Chronic Kidney Disease (CKD) include detection of reduced estimated glomerular filtration rate (eGFR) and albuminuria, which have suboptimal accuracies in predicting disease progression. The disease complexity and heterogeneity un...
作者:Harald Mischak , Klaus M. Weinberger ...
来源:[J].Journal of Clinical Lipidology(IF 2.741), 2018
摘要:Abstract(#br)Background(#br)Various alterations in lipid metabolism have been observed in patients with chronic kidney disease (CKD).(#br)Objectives(#br)To determine the levels of lipid species in plasma from CKD and hemodialysis (HD) patients and test their association with...
作者:... Peter Verhamme , Harald Mischak , Jan A. Staessen
来源:[J].Journal of the American Society of Hypertension(IF 2.835), 2018, Vol.12 (6), pp.438-447.e4
摘要:Abstract(#br)Hypertension, obesity, and old age are major risk factors for left ventricular (LV) diastolic dysfunction (LVDD), but easily applicable screening tools for people at risk are lacking. We investigated whether HF1, a urinary biomarker consisting of 85 peptides, ca...
作者:Harald Mischak , Joachim Jankowski ...
来源:[J].PLoS ONE(IF 3.73), 2017, Vol.7 (12)
摘要:Representative animal models for diabetes-associated vascular complications are extremely relevant in assessing potential therapeutic drugs. While several rodent models for type 2 diabetes (T2D) are available, their relevance in recapitulating renal and cardiovascular features of...
作者:Harald Mischak , Rudolf P Wüthrich
来源:[J].PLoS ONE(IF 3.73), 2017, Vol.6 (6)
摘要:Female patients affected by Fabry disease, an X-linked lysosomal storage disorder, exhibit a wide spectrum of symptoms, which renders diagnosis, and treatment decisions challenging. No diagnostic test, other than sequencing of the alpha-galactosidase A gene, is available and...
作者:... Thomas Koeck , Petra Zürbig , Harald Mischak
来源:[J].PLoS ONE(IF 3.73), 2017, Vol.9 (5)
摘要:Chronic kidney disease (CKD) is part of a number of systemic and renal diseases and may reach epidemic proportions over the next decade. Efforts have been made to improve diagnosis and management of CKD. We hypothesised that combining metabolomic and proteomic approaches cou...
作者:Harald Mischak , Jan A Staessen ...
来源:[J].PLoS ONE(IF 3.73), 2017, Vol.11 (6)
摘要:Biomarker discovery and new insights into the pathophysiology of heart failure with reduced ejection fraction (HFrEF) may emerge from recent advances in high-throughput urinary proteomics. This could lead to improved diagnosis, risk stratification and management of HFrEF.Urine sa...

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