全部文献期刊学位论文会议报纸专利标准年鉴图书|学者科研项目
中外文文献  中文文献  外文文献
作者:Tom V Lee , Ashutosh Pandey , Hamed Jafar-Nejad
来源:[J].PLoS Genetics(IF 8.694), 2017, Vol.13 (4)DOAJ
摘要:The Drosophila glucoside xylosyltransferase Shams xylosylates Notch and inhibits Notch signaling in specific contexts including wing vein development. However, the molecular mechanisms underlying context-specificity of the shams phenotype is not known. Considering the role of Del...
作者:... Robert S Haltiwanger , Hans Bakker , Hamed Jafar-Nejad
来源:[J].PLoS Genetics(IF 8.694), 2013, Vol.9 (6)DOAJ
摘要:The Notch signaling pathway controls a large number of processes during animal development and adult homeostasis. One of the conserved post-translational modifications of the Notch receptors is the addition of an O-linked glucose to epidermal growth factor-like (EGF) repeats with...
作者:... Yang Hong , Robert S Haltiwanger , Hamed Jafar-Nejad
来源:[J].PLoS Genetics(IF 8.694), 2014, Vol.10 (11)DOAJ
摘要:The protein O-glucosyltransferase Rumi/POGLUT1 regulates Drosophila Notch signaling by adding O-glucose residues to the Notch extracellular domain. Rumi has other predicted targets including Crumbs (Crb) and Eyes shut (Eys), both of which are involved in photoreceptor develo...
作者:Hamed Jafar-Nejad , Carmen Paradas
来源:[J].Stem Cell Research(IF 4.467), 2017, Vol.24 (C), pp.102-105DOAJ
摘要:Recently, a new type of limb-girdle muscular dystrophy (LGMD type 2Z) has been identified due to a missense mutation in POGLUT1 (protein O-glucosyltransferase-Rumi), an enzyme capable of adding glucose to a distinct serine residue of epidermal growth factor-like repeats cont...
作者:Hamed Jafar-Nejad , Hillary K. Andrews ...
来源:[J].Developmental Cell(IF 12.861), 2005, Vol.9 (3), pp.351-363Elsevier
摘要:Summary(#br)Asymmetric division of sensory organ precursors (SOPs) in Drosophila generates different cell types of the mature sensory organ. In a genetic screen designed to identify novel players in this process, we have isolated a mutation in Drosophila sec15 , which encode...
作者:Hamed Jafar-Nejad , Koenraad K. Norga , Hugo J. Bellen
来源:[J].Developmental Cell(IF 12.861), 2002, Vol.3 (2), pp.155-156Elsevier
摘要:Abstract(#br)During sensory organ precursor divisions in Drosophila, the numb gene product segregates asymmetrically into one of the two daughter cells, to which it confers a specific fate by inhibiting Notch signaling. In this issue of Developmental Cell , Berdnik et al. sh...
作者:Hamed Jafar-Nejad , Hideyuki Takeuchi ...
来源:[J].Cell(IF 31.957), 2007, Vol.132 (2), pp.247-258Elsevier
摘要:Summary(#br)Notch signaling is broadly used to regulate cell-fate decisions. We have identified a gene, rumi, with a temperature-sensitive Notch phenotype. At 28°C–30°C, rumi clones exhibit a full-blown loss of Notch signaling in all tissues tested. However, at 18°C onl...
作者:Tom V. Lee , Hideyuki Takeuchi , Hamed Jafar-Nejad
来源:[J].Methods in Enzymology(IF 2.002), 2010, Vol.480, pp.375-398Elsevier
摘要:Abstract(#br)Recent work using Drosophila melanogaster has shown that a protein O- glucosyltransferase called Rumi regulates Notch signaling. Studies on several alleles of rumi identified in a forward genetic screen indicated that Rumi is a temperature-sensitive regulator of Notc...
作者:Hamed Jafar-Nejad , Akash J. Patel ...
来源:[J].Cell(IF 31.957), 2005, Vol.122 (4), pp.633-644Elsevier
摘要:Summary(#br)Spinocerebellar ataxia type 1 (SCA1) is a neurodegenerative disease caused by an expanded glutamine tract in human Ataxin-1 (hAtx-1). The expansion stabilizes hAtx-1, leading to its accumulation. To understand how stabilized hAtx-1 induces selective neuronal dege...

我们正在为您处理中,这可能需要一些时间,请稍等。

资源合作:cnki.scholar@cnki.net, +86-10-82896619   意见反馈:scholar@cnki.net

×