全部文献期刊会议图书|学者科研项目
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作者:Héric Valette , Bertrand Kuhnast ...
来源:[J].European Journal of Pharmaceutical Sciences(IF 2.987), 2016, Vol.91, pp.98-104
摘要:Abstract(#br)Cyclosporin A (CsA) and dipyridamole (DPy) are potent inhibitors of the P-glycoprotein (P-gp; ABCB1) in vitro . Their efficacy at inhibiting P-gp at the blood-brain barrier (BBB) is difficult to predict. Efficient and readily available ( i.e. marketed) P-gp inhi...
作者:Héric Valette , Frédéric Dollé ...
来源:[J].Nuclear Medicine and Biology(IF 2.517), 1999, Vol.26 (1), pp.105-109
摘要:Abstract(#br)ABSTRACT. (±)-3-[ 11 C]Methyl-2-[4-[3-( tert -butylamino)-2-hydroxypropoxy]phenyl]-6-methoxy-4( 3H )-quinazolinone ([±]-[ 11 C]HX-CH 44) was labeled with carbon-11 using [ 11 C]iodomethane with the corresponding N -demethylated precursor. Then, 30–90 mCi (1...
作者:Héric Valette , André Syrota ...
来源:[J].European Journal of Pharmacology(IF 2.592), 1996, Vol.306 (1), pp.133-138
摘要:Abstract(#br)The muscarinic receptor antagonist methyl-quinuclidinyl-benzylate decreased myocardial β-adrenoceptor density B max : 20.4 ± 2.4 pmol/ml tissue versus 33.3 ± 4 pmol/ml tissue in control dogs ( P < 0.001), as assessed by using [ 11 C]CGP-12177 (((2 S )-4-(3- t -b...
作者:Héric Valette , Michel Bottlaender ...
来源:[J].Life Sciences(IF 2.555), 1998, Vol.64 (5), pp.PL93-PL97
摘要:Abstract(#br)The biodistribution of the nicotinic acetylcholine receptor (nAChR) radioligand 2-[ 18 F]fluoro-3-[2(S)-2-azetidinylmethoxy]pyridine ([ 18 F]fluoro-A-85380, half-life of fluorine-18 = 110 min) in selected rat brain areas was assessed in vivo. The radiotracer showed a...
作者:Héric Valette , Frédéric Dollé ...
来源:[J].Nuclear Medicine and Biology(IF 2.517), 2002, Vol.29 (8), pp.849-853
摘要:Abstract(#br)The potential mutagenic properties (micronucleus and the Ames tests) of fluoro-A-85380 (2-fluoro-3-[2(S)-2-azetidinylmethoxy]pyridine) were evaluated as a mandatory pre-clinical step. No statistically significant increase in the frequency of micronucleated polychroma...
作者:... Frédéric Dollé , Michel Bottlaender , Héric Valette
来源:[J].Nuclear Medicine and Biology(IF 2.517), 2013, Vol.40 (7), pp.887-895
摘要:Abstract(#br)Introduction(#br)[ 18 F]Fallypride, a fluorinated and substituted benzamide with high affinity for D 2 /D 3 receptors, is a useful PET radioligand for the study of striatal/extrastriatal areas. Since [ 18 F]fallypride is extensively metabolized in vivo and since...
作者:... Christian Crouzel , Emmanuel Brouillet , Héric Valette
来源:[J].Nuclear Medicine and Biology(IF 2.517), 1996, Vol.23 (4), pp.509-512
摘要:Abstract(#br)N (ω)-nitro- l -arginine methyl ester ( l -NAME) was labelled with carbon-11 as a potential PET tracer for NO synthase. N (α)- t -butoxycarbonyl- N (ω)-nitro- l -arginine was reacted with [ 11 C]diazomethane. After deprotection with trifluoroacetic acid the form...
作者:... Sébastien Goutal , Michel Bottlaender , Héric Valette
来源:[J].Nuclear Medicine and Biology(IF 2.517), 2012, Vol.39 (2), pp.227-233
摘要:Abstract(#br)Background(#br)LBT-999 (E)- N -(4-fluorobut-2-enyl)-2β-carbomethoxy-3β-(4′-tolyl)nortropane is a dopamine transporter (DAT) ligand. [ 18 F]LBT-999 was first labelled with carbon-11; we will now describe its in vivo behaviour in comparison to that of [ 11 C]LBT-9...
作者:... Christine Coulon , Michel Bottlaender , Héric Valette
来源:[J].Nuclear Medicine and Biology(IF 2.517), 2012, Vol.39 (3), pp.347-359
摘要:Abstract(#br)Introduction(#br)LBT-999, ( E )- N -(4-fluorobut-2-enyl)-2β-carbomethoxy-3β-(4'-tolyl)nortropane, has been developed for PET imaging of the dopamine transporter. [ 18 F]LBT-999 PET studies in baboons showed a lower brain uptake than [ 11 C]LBT-999 and a high bon...

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