全部文献期刊学位论文会议报纸专利标准年鉴图书|学者科研项目
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作者:Guoqiang Chang , Zhenqing Xie ...
来源:[J].Cellular Physiology and Biochemistry(IF 3.415), 2014, Vol.33 (1), pp.185-194DOAJ
摘要:Background/Aims: Na+/H+ exchanger 1 (NHE1) is an important regulator of intracellular pH (pHi). High pHi is required for cell proliferation and differentiation. Our previous study has proven that the pHi of mesenchymal stem cells is higher than that of normal differentiated ...
作者:Guoqiang Chang , Jia-Shiun Leu ...
来源:[J].Cytokine(IF 2.518), 2019, Vol.118, pp.35-41Elsevier
摘要:Abstract(#br)Among myriads of distinct chemical modification in RNAs, the dynamic, reversible and fine-tuned methylation of N 6 -methyladenosine (m 6 A) is the most prevalent modification in eukaryotic mRNAs. This RNA mark is generated by proteins that act as m 6 A writers and ca...
作者:Guoqiang Chang , Yani Lin
来源:[J].International Journal of Biochemistry and Cell Biology(IF 4.152), 2014, Vol.54, pp.111-121Elsevier
摘要:Abstract(#br)In our previous study, we have found that the tumor multidrug resistance mediated by P-glycoprotein could be reversed by sustained intracellular acidification through down-regulating the multidrug resistance gene 1 mRNA and P-glycoprotein expression. However, the mol...
作者:Guoqiang Chang , Jian Wang ...
来源:[J].Leukemia Research(IF 2.764), 2013, Vol.37 (11), pp.1583-1591Elsevier
摘要:Abstract(#br)CUEDC2, a newly reported protein, has been found to be ubiquitously expressed in human tissues and repress NF-κB activity. To study the role of CUEDC2 in chronic myeloid leukemia (CML), we explored the function of CUEDC2 in CML cells through using the CML cell l...
作者:Guoqiang Chang , Jian Wang ...
来源:[J].Experimental Cell Research(IF 3.557), 2011, Vol.317 (14), pp.2031-2040Elsevier
摘要:Abstract(#br)Na + /H + exchanger 1 (NHE1), an important regulator of intracellular pH (pH i ) and extracellular pH (pH e ), has been shown to play a key role in breast cancer metastasis. However, the exact mechanism by which NHE1 mediates breast cancer metastasis is not yet well ...
作者:Guoqiang Chang , Ruojun Wang ...
来源:[J].BBA - Molecular Cell Research(IF 4.808), 2011, Vol.1813 (10), pp.1803-1813Elsevier
摘要:Abstract(#br)Breast cancer is a leading cause of morbidity in women worldwide. neutrophil gelatinase-associated lipocalin (NGAL), a useful biomarker of ER negative (ER − ) breast cancer, promotes local tumor invasion and lymph node metastasis. We first identified the distinc...
作者:Guoqiang Chang , Jian Wang ...
来源:[J].Leukemia Research(IF 2.764), 2011, Vol.35 (11), pp.1506-1511Elsevier
摘要:Abstract(#br)To investigate the effect of inhibition of Na + /H + exchanger isoform1 (NHE1) on K562 leukemia-driven angiogenesis, the selective NHE1 inhibitor cariporide was used. Cariporide treatment of K562 resulted in a decrease in pHi and down-regulation of VEGF secretion. Th...

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