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作者:Guillermo P. Vicent , Marı́a J. Meliá , Miguel Beato
来源:[J].Journal of Molecular Biology(IF 3.905), 2002, Vol.324 (3), pp.501-517
摘要:Abstract(#br)Packaging of mouse mammary tumor virus (MMTV) promoter sequences in nucleosomes modulates access of DNA binding proteins and influences the interaction among DNA bound transcription factors. Here we analyze the binding of histone H1 to MMTV mononucleosomes assem...
作者:Guillermo P. Vicent , Cecilia Ballaré ...
来源:[J].Molecular Cell(IF 15.28), 2006, Vol.24 (3), pp.367-381
摘要:Summary(#br)How genes are regulated in the context of chromatin is a central question of biology. Steroid hormones control gene expression via interaction of their receptors with target sequences on DNA but can also activate cytoplasmic signaling cascades. Here we report tha...
作者:Guillermo P. Vicent , A.Silvina Nacht ...
来源:[J].Molecular Cell(IF 15.28), 2004, Vol.16 (3), pp.439-452
摘要:Abstract(#br)Regulation of gene expression requires dynamic changes in chromatin, but the nature of these changes is not well understood. Here, we show that progesterone treatment of cultured cells leads to recruitment of progesterone receptor (PR) and SWI/SNF-related complexes t...
作者:Guillermo P. Vicent , Adalı́ Pecci ...
来源:[J].Experimental Cell Research(IF 3.557), 2002, Vol.276 (2), pp.142-154
摘要:Abstract(#br)We studied the glucocorticoid response to the synthetic steroid pregna-1,4-diene-11β-ol-3,20-dione (ΔHOP) in several cell types and correlated its biological effect with the ability of the glucocorticoid receptor (GR) to be retained in the nuclear compartment. W...
作者:Guillermo P. Vicent , Cecilia Ballaré ...
来源:[J].Journal of Steroid Biochemistry and Molecular Biology(IF 3.984), 2008, Vol.109 (3), pp.344-349
摘要:Abstract(#br)Gene regulation by steroid hormones involves genomic and non-genomic signaling pathways and the relationship between these two pathways is unknown. Genomic actions are often mediated by binding of the ligand-activated hormone receptors to hormone responsive elem...
作者:Guillermo P. Vicent , Patricia Saragüeta
来源:[J].Journal of Steroid Biochemistry and Molecular Biology(IF 3.984), 2006, Vol.102 (1), pp.2-10
摘要:Abstract(#br)In addition to transcriptional effects, steroid hormones rapidly activate cytoplasmic signaling cascades. The ultimate targets of these cascades are not well-defined and likely include transcription factors and coactivators. To better understand the role of the ...
作者:Miguel Beato , Guillermo P. Vicent
来源:[J].Molecular and Cellular Endocrinology(IF 4.039), 2012, Vol.357 (1-2), pp.37-42
摘要:Abstract(#br)Gene regulation requires access of transcription factors to DNA sequences of target genes, which is limited by the compaction of DNA in chromatin. Based on our studies on the Progesterone receptor (PR)-dependent hormonal induction of mouse mammary tumor virus (MMTV) ...
作者:Guillermo P. Vicent , Gerardo Burton
来源:[J].Steroids(IF 2.803), 1997, Vol.62 (4), pp.358-364
摘要:Abstract(#br)11β-hydroxyprogesterone (HOP) and 11-ketoprogesterone (KP) are reversible components of a shuttle pair whose interconversion in rat liver is catalyzed by isoform-1 of 11β-hydroxysteroid dehydrogenase. Kidneys also produce this interconversion. The present study ...
作者:... Daniel Soronellas , Guillermo P. Vicent , Miguel Beato
来源:[J].Molecular Cell(IF 15.28), 2013, Vol.49 (1), pp.67-79
摘要:Summary(#br)Elucidating the global function of a transcription factor implies the identification of its target genes and genomic binding sites. The role of chromatin in this context is unclear, but the dominant view is that factors bind preferentially to nucleosome-depleted regio...
作者:Guillermo P. Vicent , Francisco X. Real
来源:[J].Nature Cell Biology(IF 20.761), 2014, Vol.16 (7), pp.695-707
摘要:Abstract(#br)Aberrant activation of WNT signalling and loss of BMP signals represent the two main alterations leading to the initiation of colorectal cancer (CRC). Here we screen for genes required for maintaining the tumour stem cell phenotype and identify the zinc-finger t...

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