全部文献期刊会议图书|学者科研项目
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作者:Guangwei Du , Tohru Kataoka
来源:[J].Biochemical and Biophysical Research Communications(IF 2.406), 2020, Vol.524 (2), pp.325-331
摘要:Abstract(#br)Integrin activation by Rap1-GTP is pivotal for lymphocyte trafficking. In this study, we show the phosphatidic acid (PA)-dependent membrane distribution of RA-GEF-1 and -2 (also known as Rapgef2 and 6), which are guanine nucleotide exchange factors for Rap1, pla...
作者:Guangwei Du , Mechelle M. Lewis ...
来源:[J].Neurobiology of Aging(IF 6.166), 2019
摘要:Abstract(#br)Previous multimodal magnetic resonance imaging (MRI) studies of parkinsonian syndromes have focused primarily on motor-related basal ganglia structures. The present study investigated MRI changes in non-motor-related limbic structures in 35 Parkinson’s disease (...
作者:Guangwei Du , Jin Wang ...
来源:[J].Cell(IF 31.957), 2018, Vol.173 (4), pp.1058-1058
作者:Guangwei Du , Mechelle M. Lewis ...
来源:[J].Neurobiology of Aging(IF 6.166), 2017, Vol.49, pp.100-108
摘要:Abstract(#br)Cortical atrophy has been documented in both Parkinson's disease (PD) and healthy aging, but its relationship to changes in subcortical white matter is unknown. This was investigated by obtaining T1- and diffusion-weighted images from 76 PD and 70 controls at ba...
作者:Guangwei Du , Jin Wang ...
来源:[J].Cell(IF 31.957), 2017, Vol.169 (7), pp.1249-1262.e13
摘要:Summary(#br)Homeostasis of the gut microbiota critically influences host health and aging. Developing genetically engineered probiotics holds great promise as a new therapeutic paradigm to promote healthy aging. Here, through screening 3,983 Escherichia coli mutants, we discovere...
作者:... Wei Xie , Guangwei Du , Zhiyu Qiao
来源:[J].Calphad(IF 1.433), 2015, Vol.51, pp.241-251
摘要:Abstract(#br)The V–O system has been critically evaluated and thermodynamically assessed based on the available phase diagram and thermodynamic data using the CALPHAD method. The liquid phase over the whole composition range from metallic liquid to oxide melt is described by...
作者:Guangwei Du , Jaebum Park ...
来源:[J].Neurotoxicology(IF 2.652), 2016, Vol.56, pp.76-85
摘要:Abstract(#br)Background(#br)Multi-digit synergies, a recently developed, theory-based method to quantify stability of motor action, are shown to reflect basal ganglia dysfunction associated with parkinsonian syndromes. In this study, we tested the hypothesis that multi-digit...
作者:... Mechelle M. Lewis , Guangwei Du , Xuemei Huang
来源:[J].Parkinsonism and Related Disorders(IF 3.274), 2015, Vol.21 (5), pp.465-470
摘要:Abstract(#br)Background(#br)Parkinson's disease (PD) is a neurodegenerative disorder that generally begins with asymmetric motor symptoms that persist over time. This suggests that the dysfunction in the nigrostriatal motor circuit may be lateralized. The present study examined w...
作者:Guangwei Du , Rebecca C. Fry ...
来源:[J].Neurotoxicology(IF 2.652), 2016, Vol.57, pp.39-44
摘要:Abstract(#br)Objectives(#br)We demonstrated recently that the T1 relaxation rate (R1) captured short-term Mn exposure in welders with chronic, relatively low exposure levels in a cross-sectional study. In the current study, we used a longitudinal design to examine whether R1...
作者:Guangwei Du , Debra Babcock ...
来源:[J].NeuroImage(IF 6.252), 2016, Vol.124, pp.1120-1124
摘要:Abstract(#br)The Parkinson's Disease Biomarkers Program (PDBP) is a multi-site study designed to identify Parkinson's disease (PD) biomarkers that can be used to improve the understanding of PD pathophysiology and to develop tools that provide novel measures to evaluate PD clinic...

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