全部文献期刊会议图书|学者科研项目
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作者:... Lyuba Varticovski , Sohyoung Kim , Gordon L. Hager
来源:[J].Scientific Reports(IF 2.927), 2019, Vol.9 (1), pp.1-11DOAJ
摘要:Abstract DNA accessibility to transcription regulators varies between cells and modulates gene expression patterns. Several “open” chromatin profiling methods that provide valuable insight into the activity of these regulatory regions have been developed. However, their appl...
作者:Gordon L. Hager , Richard S. Judson ...
来源:[J].Toxicology(IF 4.017), 2017, Vol.385, pp.48-58Elsevier
摘要:Abstract(#br)The androgen receptor (AR, NR3C4) is a nuclear receptor whose main function is acting as a transcription factor regulating gene expression for male sexual development and maintaining accessory sexual organ function. It is also a necessary component of female fer...
作者:... Vicki Blazer , Luke Iwanowicz , Gordon L. Hager
来源:[J].Toxicology(IF 4.017), 2016, Vol.368-369, pp.69-79Elsevier
摘要:Abstract(#br)Even though the presence of endocrine disrupting chemicals (EDCs) with thyroid hormone (TH)-like activities in the environment is a major health concern, the methods for their efficient detection and monitoring are still limited. Here we describe a novel cell as...
作者:... Laura E. Beane Freeman , Gordon L. Hager , Mary H. Ward
来源:[J].Science of the Total Environment(IF 3.258), 2020, Vol.714Elsevier
摘要:Abstract(#br)Some anthropogenic substances in drinking water are known or suspected endocrine disrupting compounds (EDCs), but EDCs are not routinely measured. We conducted a pilot study of 10 public drinking water utilities in Iowa, where common contaminants (e.g., pesticides) a...
作者:... Alberto Villanueva , Gordon L. Hager , Montse Sanchez‐Cespedes
来源:[J].EMBO Molecular Medicine(IF 7.795), 2012, Vol.4 (7), pp.603-616Wiley
摘要:Abstract(#br)BRG1, a member of the SWI/SNF complex, is mutated in cancer, but it is unclear how it promotes tumourigenesis. We report that re‐expression of BRG1 in lung cancer cells up‐regulates lung‐specific transcripts, restoring the gene expression signature of norma...
作者:... Angie B. Dull , Dawn A. Walker , Gordon L. Hager
来源:[J].Journal of Steroid Biochemistry and Molecular Biology(IF 3.984), 2005, Vol.97 (4), pp.307-321Elsevier
摘要:Abstract(#br)We have developed a new mammalian cell-based assay to screen for ligands of the estrogen receptor. A fluorescently tagged chimera between the glucocorticoid and the estrogen receptors, unlike the constitutively nuclear estrogen receptor, is cytoplasmic in the ab...
作者:Gordon L. Hager , Cheryl H. Arrowsmith ...
来源:[J].Cancer Cell(IF 24.755), 2017, Vol.31 (1), pp.50-63Elsevier
摘要:Summary(#br)Given the paucity of druggable mutations in high-risk neuroblastoma (NB), we undertook chromatin-focused small interfering RNA and chemical screens to uncover epigenetic regulators critical for the differentiation block in high-risk NB. High-content Opera imaging iden...
作者:... Iain D.C. Fraser , Gordon L. Hager , Myong-Hee Sung
来源:[J].Immunity(IF 19.795), 2017, Vol.47 (2), pp.298-309.e5Elsevier
摘要:Summary(#br)Despite the widespread use of glucocorticoids (GCs), their anti-inflammatory effects are not understood mechanistically. Numerous investigations have examined the effects of glucocorticoid receptor (GR) activation prior to inflammatory challenges. However, clinic...
作者:... Luke D. Lavis , Tatiana S. Karpova , Gordon L. Hager
来源:[J].Methods(IF 3.641), 2017, Vol.123, pp.76-88Elsevier
摘要:Abstract(#br)Progressive, technological achievements in the quantitative fluorescence microscopy field are allowing researches from many different areas to start unraveling the dynamic intricacies of biological processes inside living cells. From super-resolution microscopy techn...

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