全部文献期刊会议图书|学者科研项目
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作者:... Hao Lei , Jian-Zhi Wang , Gong-Ping Liu
来源:[J].Molecular Neurobiology(IF 5.471), 2017, Vol.54 (6), pp.4160-4171
摘要:Fluoxetine, a selective serotonin reuptake inhibitor, is neuroprotective; therefore, it has been applied to treat some neurodegenerative disorders. For instance, chronic fluoxetine exposure has short-term effects on Alzheimer’s disease (AD). However, the long-term ameliorati...
作者:... Hong-Lian Li , Gong-Ping Liu , Jian-Zhi Wang
来源:[J].Molecular Neurodegeneration(IF 4.007), 2017, Vol.12 (1)
摘要:The impairment of histone acetylation is causally linked to the cognitive decline in Alzheimer’s disease (AD). In addition to histone acetyltransferases (HATs) and histone deacetylases (HDACs), inhibitor of acetyltransferases (INHAT) can also regulate histone acetylation. As...
作者:... Jun-fei Zhang , Jian-Zhi Wang , Gong-ping Liu
来源:[J].Journal of Huazhong University of Science and Technology [Medical Sciences](IF 0.581), 2017, Vol.37 (3), pp.307-312
摘要:As a major microtubule-associated protein, tau plays an important role in promoting microtubule assembly and stabilizing microtubules. In Alzheimer’s disease (AD) and other tauopathies, the abnormally hyperphosphorylated tau proteins are aggregated into paired helical filame...
作者:... Dan Ke , Xi-Fei Yang , Gong-Ping Liu
来源:[J].Neuroscience Letters(IF 2.026), 2018, Vol.682, pp.39-44
摘要:Abstract(#br)Epidemiological surveys show that 70–80% of patients with Alzheimer’s disease (AD) have type 2 diabetes mellitus (T2DM) or show an abnormality of blood glucose levels. Therefore, an increasing number of evidence has suggested that diabetic hyperglycemia is tight...
作者:... Jie Wang , Gong-Ping Liu , Jian-Zhi Wang
来源:[J].Molecular Therapy(IF 7.041), 2017, Vol.25 (1), pp.140-152
摘要:Patients with Alzheimer’s disease (AD) commonly show anxiety behaviors, but the molecular mechanisms are not clear and no efficient intervention exists. Here, we found that overexpression of human wild-type, full-length tau (termed htau) in hippocampus significantly decrease...
作者:... Xiao Li , Dan-Ju Luo , Gong-Ping Liu
来源:[J].Neuroscience Letters(IF 2.026), 2019, Vol.705, pp.151-158
摘要:Abstract(#br)Drosophila egg-derived tyrosine phosphatase (EDTP), a lipid phosphatase that removes 3-position phosphate at the inositol ring, has dual functions in oogenesis and muscle performance in adults. A mammalian homologous gene MTMR14 , which encodes the myotubularin-...
作者:... Hao Lei , Jian-Zhi Wang , Gong-Ping Liu
来源:[J].Neuropharmacology(IF 4.114), 2017, Vol.126, pp.200-212
摘要:Abstract(#br)Fluoxetine (FLX) has broad neurobiological functions and neuroprotective effects; however, the preventive effects of FLX on cognitive impairments in Alzheimer's disease (AD) have not been reported. Here, we studied whether adolescent administration of fluoxetine...
作者:... Yao Zhang , Gong-Ping Liu , Jian-Zhi Wang
来源:[J].PLoS ONE(IF 3.73), 2017, Vol.9 (9)
摘要:Alzheimer's disease (AD) is characterized by profound synapse loss and impairments of learning and memory. Magnesium affects many biochemical mechanisms that are vital for neuronal properties and synaptic plasticity. Recent studies have demonstrated that the serum and brain ...
作者:Gong-Ping Liu , Cheng Xu ...
来源:[J].PLoS ONE(IF 3.73), 2017, Vol.10 (3)
摘要:Tau is a microtubule-associated protein implicated in neurodegenerative tauopathies. Six tau isoforms are generated from a single gene through alternative splicing of exons 2, 3 and 10 in human brain. Differential expression of tau isoforms has been detected in different brain ar...

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