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作者:... Huitong Ding , Ning An , Gil Alterovitz
来源:[J].BMC Bioinformatics(IF 3.024), 2017, Vol.18 (1)Springer
摘要:Visualizing data by dimensionality reduction is an important strategy in Bioinformatics, which could help to discover hidden data properties and detect data quality issues, e.g. data noise, inappropriately labeled data, etc. As crowdsourcing-based synthetic biology databases face...
作者:Amin Zollanvari , Gil Alterovitz
来源:[J].BMC Systems Biology(IF 2.982), 2017, Vol.11 (3)Springer
摘要:Alcoholism has a strong genetic component. Twin studies have demonstrated the heritability of a large proportion of phenotypic variance of alcoholism ranging from 50–80%. The search for genetic variants associated with this complex behavior has epitomized sequence-based stud...
作者:Arnav Kapur , Kshitij Marwah , Gil Alterovitz
来源:[J].BMC Bioinformatics(IF 3.024), 2016, Vol.17 (1)Springer
摘要:Abstract(#br) Background(#br)An exponential growth of high-throughput biological information and data has occurred in the past decade, supported by technologies, such as microarrays and RNA-Seq. Most data generated using such methods are used to encode large amounts of rich infor...
作者:... Yinsheng Wei , Bingfei Li , Gil Alterovitz
来源:[J].Sensors(IF 1.953), 2014, Vol.14 (9), pp.16046-16061DOAJ
摘要:A constant false alarm rate (CFAR) target detector in non-homogenous backgrounds is proposed. Based on K-sample Anderson-Darling (AD) tests, the method re-arranges the reference cells by merging homogenous sub-blocks surrounding the cell under test (CUT) into a new reference wind...
作者:... Robin Ruthazer , Ruby L. Russell , Gil Alterovitz
来源:[J].The Journal of Pediatrics(IF 4.035), 2015, Vol.166 (2), pp.282-288.e5Elsevier
摘要:Objective(#br)To combine mathematical modeling of salivary gene expression microarray data and systems biology annotation with reverse-transcription quantitative polymerase chain reaction amplification to identify (phase I) and validate (phase II) salivary biomarker analysis for ...
作者:... Guilin Chen , Lian Li , Gil Alterovitz
来源:[J].Computers in Biology and Medicine(IF 1.162), 2017, Vol.81, pp.11-23Elsevier
摘要:Abstract(#br)Gene selection seeks to find a small subset of discriminant genes from the gene expression profiles. Current gene selection methods such as wrapper-based models mainly address the issue of obtaining high-quality gene subsets. However, they are considerably time consu...
作者:... Wenhua Zeng , Beizhan Wang , Gil Alterovitz
来源:[J].Information Sciences(IF 3.643), 2019, Vol.505, pp.535-548Elsevier
摘要:Abstract(#br)Collaborative filtering (CF) approaches are widely applied in recommender systems. Traditional CF approaches have high costs to train the models and cannot capture changes in user interests and item popularity. Most CF approaches assume that user interests remain unc...
作者:... Bowen Gong , Ning An , Gil Alterovitz
来源:[J].Computers in Biology and Medicine(IF 1.162), 2017, Vol.86, pp.31-39Elsevier
摘要:Abstract(#br)Synthetic biology databases have collected numerous biobricks to accelerate genetic circuit design. However, selecting biobricks is a tough task. Here, we leverage the fact that these manually designed circuits can provide underlying knowledge to support biobrick sel...
作者:... Guilin Chen , Li Liu , Gil Alterovitz
来源:[J].Knowledge-Based Systems(IF 4.104), 2018, Vol.146, pp.104-117Elsevier
摘要:Abstract(#br)Gene expression profiles are being used to categorize disease specific genes and classify different tumor subtypes at the molecular level. Due to the inherent nature of these data having high dimensionality and small sample sizes, current conventional machine learnin...
作者:Gil Alterovitz , Lei Cheng
来源:[J].Applied Microbiology and Biotechnology(IF 3.689), 2018, Vol.102 (12), pp.5255-5264Springer
摘要:Abstract(#br)The increase of fungal infectious diseases and lack of safe and efficacious antifungal drugs result in the urgent need of new therapeutic strategies. Here, we repurposed the lovastatin (LOV) as a synergistic antifungal potentiator to itraconazole (ITZ) against Candid...

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