全部文献期刊学位论文会议报纸专利标准年鉴图书|学者科研项目
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作者:... Reid Robison , Kai Wang , Gholson J. Lyon
来源:[J].BMC Medical Genomics(IF 3.466), 2017, Vol.10 (1)Springer
摘要:Human Phenotype Ontology (HPO) has risen as a useful tool for precision medicine by providing a standardized vocabulary of phenotypic abnormalities to describe presentations of human pathologies; however, there have been relatively few reports combining whole genome sequencing (W...
作者:Gholson J. Lyon , Robert A. King ...
来源:[J].European Child & Adolescent Psychiatry(IF 3.699), 2018, Vol.27 (5), pp.569-579Springer
摘要:Abstract(#br)Trichotillomania/hair pulling disorder (HPD) and excoriation/skin picking disorder (SPD) are childhood-onset, body-focused repetitive behaviors that are thought to share genetic susceptibility and underlying pathophysiology with obsessive–compulsive disorder (OC...
作者:Gholson J. Lyon
来源:[J].Structure(IF 5.994), 2019, Vol.27 (7), pp.1053-1055Elsevier
摘要:In this issue of Structure , Deng et al. (2019) determine the structure of the yeast N-terminal acetyltransferases Naa10 and Naa50 in complex with Naa15 and demonstrate that Naa50 has negligible catalytic activity on its own but modulates Naa10/Naa15. This study provides insights...
作者:Max J. Dörfel , Gholson J. Lyon
来源:[J].Gene(IF 2.196), 2015, Vol.567 (2), pp.103-131Elsevier
摘要:Abstract(#br)N-terminal acetylation (NTA) is one of the most abundant protein modifications known, and the N-terminal acetyltransferase (NAT) machinery is conserved throughout all Eukarya. Over the past 50 years, the function of NTA has begun to be slowly elucidated, and thi...
作者:Jason A. O’Rawe , Scott Ferson , Gholson J. Lyon
来源:[J].Trends in Genetics(IF 9.772), 2015, Vol.31 (2), pp.61-66Elsevier
摘要:Science is defined in part by an honest exposition of the uncertainties that arise in measurements and propagate through calculations and inferences, so that the reliabilities of its conclusions are made apparent. The recent rapid development of high-throughput DNA sequencing tec...
作者:... Michael Klingener , Jake Weiser , Gholson J. Lyon
来源:[J].Yeast(IF 1.955), 2017, Vol.34 (1), pp.19-37Wiley
摘要:Abstract(#br)Naa10 is an Nα ‐terminal acetyltransferase that, in a complex with its auxiliary subunit Naa15, co‐translationally acetylates the α ‐amino group of newly synthetized proteins as they emerge from the ribosome. Roughly 40–50% of the human prot...
作者:Gholson J. Lyon , Richard P. Novick
来源:[J].Peptides(IF 2.522), 2003, Vol.25 (9), pp.1389-1403Elsevier
摘要:Abstract(#br)There are two basic types of bacterial communication systems—those in which the signal is directed solely at other organisms and those in which the signal is sensed by the producing organism as well. The former are involved primarily in conjugation; the latter i...
作者:Gholson J. Lyon , David Shprecher ...
来源:[J].Current Treatment Options in Neurology(IF 1.938), 2010, Vol.12 (4), pp.274-286Springer
摘要:Opinion statement(#br)Tourette’s disorder (TD) is a common childhood-onset neuropsychiatric disorder characterized by chronic motor and vocal tics. TD frequently occurs with other neuropsychiatric disorders, such as attention deficit hyperactivity disorder (ADHD) and obsessi...

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