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作者:Katerina C. Nastou , Georgios N. Tsaousis , Vassiliki A. Iconomidou
来源:[J].BBA - Biomembranes(IF 3.389), 2020, Vol.1862 (2)
摘要:Abstract(#br)The majority of all proteins in cells interact with membranes either permanently or temporarily. Peripheral membrane proteins form transient complexes with membrane proteins and/or lipids, via non-covalent interactions and are of outmost importance, due to numer...
作者:Georgios N. Tsaousis , George Mertzanos ...
来源:[J].Hellenic Journal of Cardiology(IF 1.227), 2020
摘要:Abstract(#br)Background(#br)Several microRNA polymorphisms have been associated with susceptibility to specific health disorders, including cardiovascular diseases. The aim of the present study was to investigate whether four well-studied miRNA polymorphisms in non-Caucasian...
作者:Georgios N. Tsaousis , Eirini Papadopoulou ...
来源:[J].Cancer Genetics(IF 1.915), 2018, Vol.220, pp.1-12
摘要:Germline mutations in the BRCA1 and BRCA2 genes are associated with hereditary predisposition to breast and ovarian cancer. Sensitive and accurate detection of BRCA1 and BRCA2 mutations is crucial for personalized clinical management of individuals affected by breast or ovarian c...
作者:Georgios N. Tsaousis , Nikos C. Papandreou
来源:[J].BBA - Proteins and Proteomics(IF 3.733), 2016, Vol.1864 (7), pp.747-754
摘要:Abstract(#br)A large number of modular domains that exhibit specific lipid binding properties are present in many membrane proteins involved in trafficking and signal transduction. These domains are present in either eukaryotic peripheral membrane or transmembrane proteins and ar...
作者:Georgios N. Tsaousis , Pantelis G. Bagos , Stavros J. Hamodrakas
来源:[J].BBA - Proteins and Proteomics(IF 3.733), 2014, Vol.1844 (2), pp.316-322
摘要:Abstract(#br)During the last two decades a large number of computational methods have been developed for predicting transmembrane protein topology. Current predictors rely on topogenic signals in the protein sequence, such as the distribution of positively charged residues in ext...
作者:Ioly Kotta-Loizou , Georgios N. Tsaousis , Stavros J. Hamodrakas
来源:[J].BBA - Proteins and Proteomics(IF 3.733), 2013, Vol.1834 (4), pp.798-807
摘要:Abstract(#br)Molecular Recognition Features (MoRFs) are defined as short, intrinsically disordered regions in proteins that undergo disorder-to-order transition upon binding to their partners. As their name suggests, they are implicated in molecular recognition, which serves...
作者:Georgios N. Tsaousis , Kimon E. Kremizas ...
来源:[J].BioMed Research International, 2014, Vol.2014
摘要:A major part of membrane function is conducted by proteins, both integral and peripheral. Peripheral membrane proteins temporarily adhere to biological membranes, either to the lipid bilayer or to integral membrane proteins with noncovalent interactions. The aim of this study was...
作者:Georgios N. Tsaousis , Eirini Papadopoulou ...
来源:[J].BMC Cancer(IF 3.333), 2019, Vol.19 (1), pp.1-19
摘要:Abstract Background Hereditary cancer predisposition syndromes are responsible for approximately 5–10% of all diagnosed cancer cases. In the past, single-gene analysis of specific high risk genes was used for the determination of the genetic cause of cancer heritability in c...
作者:Georgios N. Tsaousis , Georgia Pepe ...
来源:[J].BMC Medical Genetics(IF 2.536), 2019, Vol.20 (1), pp.1-4
摘要:Abstract Background CHEK2 is involved in the DNA damage repair response Fanconi anemia (FA)-BRCA pathway. An increased risk for breast and other cancers has been documented in individuals who carry a single pathogenic CHEK2 variant. As for other genes involved in cancer pred...

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