全部文献期刊学位论文会议报纸专利标准年鉴图书|学者科研项目
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作者:Georgios A. Dalkas , Marianne Rooman
来源:[J].BMC Bioinformatics(IF 3.024), 2017, Vol.18 (1)Springer
摘要:The identification of immunogenic regions on the surface of antigens, which are able to be recognized by antibodies and to trigger an immune response, is a major challenge for the design of new and effective vaccines. The prediction of such regions through computational immunolog...
作者:Georgios A. Dalkas , Eugenia Katsoulakou ...
来源:[J].Journal of Inorganic Biochemistry(IF 3.197), 2014, Vol.134, pp.12-19Elsevier
摘要:Abstract(#br)In order to investigate the ability of metal complexes to act as reactivators of organophosphorus compounds (OP)-inhibited acetylcholinesterase (AChE), we have synthesized and crystallographically characterized three novel mononuclear Zn II complexes formulated ...
作者:Georgios A. Dalkas , Christos T. Chasapis ...
来源:[J].Biochemical and Biophysical Research Communications(IF 2.406), 2010, Vol.396 (3), pp.643-647Elsevier
摘要:Abstract(#br)Anthrax lethal toxin (LeTx) stands for the major virulence factor of the anthrax disease. It comprises a 90 kDa highly specific metalloprotease, the anthrax lethal factor (LF). LF possesses a catalytic Zn 2+ binding site and is highly specific against MAPK kinas...
作者:Georgios A. Dalkas , Fabian Teheux ...
来源:[J].Proteins: Structure, Function, and Bioinformatics(IF 3.337), 2014, Vol.82 (9), pp.1734-1746Wiley
摘要:ABSTRACT(#br)The identification of immunogenic regions on the surface of antigens, which are able to stimulate an immune response, is a major challenge for the design of new vaccines. Computational immunology aims at predicting such regions—in particular B‐cell epitopes...
作者:Georgios A. Dalkas , Damien Marchand ...
来源:[J].Journal of Peptide Science(IF 2.071), 2010, Vol.16 (2), pp.91-97Wiley
摘要:Abstract(#br)Human ACE is a central component of the renin–angiotensin system and a major therapeutic target for cardiovascular diseases. The somatic form of the enzyme (sACE) comprises two homologous metallopeptidase domains (N and C), each bearing a zinc active site with s...
作者:Georgios A. Dalkas , Christos T. Chasapis ...
来源:[J].Proteins: Structure, Function, and Bioinformatics(IF 3.337), 2011, Vol.79 (1), pp.142-152Wiley
摘要:Abstract(#br)Based on the crystal structure of the extracellular domain (ECD) of the mouse nicotinic acetylcholine receptor (nAChR) alpha1 subunit bound to α‐bungarotoxin (α‐Btx) we have generated in silico models of the human nAChR α1 bound to α‐Btx and α‐cobratox...
作者:Georgios A. Dalkas , Dimitrios Vlachakis ...
来源:[J].Briefings in Bioinformatics(IF 5.298), 2013, Vol.14 (6), pp.745-752Oxford U Press
摘要:The quest for small drug-like compounds that selectively inhibit the function of biological targets has always been a major focus in the pharmaceutical industry and in academia as well. High-throughput screening of compound libraries requires time, cost and resources. Therefore, ...

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