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作者:Geoffrey Goldspink
来源:[J].International Journal of Biochemistry and Cell Biology(IF 4.152), 2005, Vol.38 (3), pp.481-489
摘要:Abstract(#br)The characterisation of a local tissue repair factor (mechano growth factor, MGF) that is produced by exercised and/or damaged muscle by differential splicing of the IGF-I gene provides understanding of how muscle is maintained in the young normal individual. Mechano...
作者:Geoffrey Goldspink
来源:[J].Journal of Thermal Biology(IF 1.376), 1995, Vol.20 (1), pp.167-174
摘要:Abstract(#br)In fish that coccupy a specific thermal habitat the contractile apparatus has been adapted during evolution for that specific temperature range. In Antarctic fish the myofibrillar ATPase activity is relatively high at temperatures around 0°C, but this is at the ...
作者:Geoffrey Goldspink
来源:[J].Comparative Biochemistry and Physiology, Part B(IF 2.069), 1998, Vol.120 (1), pp.5-15
摘要:Abstract(#br)Muscle is a very adaptable tissue in which gene expression is to a large extent influenced by physical signals. Adaptation to a different work regime is brought about by changes in fibre type and fibre cross-sectional area. We have shown both mass and phenotype are m...
作者:Geoffrey Goldspink , Stephen D.R. Harridge
来源:[J].Experimental Gerontology(IF 3.911), 2004, Vol.39 (10), pp.1433-1438
摘要:Abstract(#br)Loss of muscle mass (sarcopenia) is one of the main problems associated with ageing as it has major health care as well as socioeconomic implications. The growth hormone (GH)/IGF-I axis is regarded as an important regulator of muscle mass. However, it is now app...
作者:Geoffrey Goldspink
来源:[J].International Journal of Biochemistry and Cell Biology(IF 4.152), 2005, Vol.37 (10), pp.2012-2022
摘要:Abstract(#br)An aminopeptidase was purified from bovine skeletal muscle by ammonium sulfate fractionation and by successive chromatographies of DEAE-cellulose, Sehacryl S-200, phenyl-sepharose CL-4B, hydroxyapatite and Hi-Trap chelating HP columns. The aminopeptidase was pur...
作者:Geoffrey Goldspink , Barbara Wessner , Norbert Bachl
来源:[J].Current Opinion in Pharmacology(IF 5.443), 2008, Vol.8 (3), pp.352-357
摘要:Recently much interest has been shown in developing a treatment of muscle wasting associated with a range of diseases as well as in ageing, which are major medical and socioecomonic problems. Emerging molecular techniques have made it possible to gain a better understanding ...

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