全部文献期刊学位论文会议报纸专利标准年鉴图书|学者科研项目
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作者:... Kosuke Nishi , In-Hae Kim , Gennady M. Butov
来源:[J].Chemistry of Heterocyclic Compounds(IF 0.634), 2017, Vol.53 (10), pp.1080-1083Springer
摘要:A series of 1,3-(adamantan-1(2)-yl)imidazolidine-2,4,5-triones and 1,1'-(alkane-1,n-diyl)bis[3-(adamantan-1-yl)imidazolidine-2,4,5-triones] was synthesized via cyclization of 1,3-bis[adamantan-1(2)-ylureas] and 1,1'-(alkyl-1,n-diyl)bis[3-(adamantan-1-yl)ureas] with oxalyl ch...
作者:... Vladimir V. Vasipov , Vladimir S. D’yachenko , Gennady M. Butov
来源:[J].Chemistry of Heterocyclic Compounds(IF 0.634), 2019, Vol.55 (7), pp.619-622Springer
摘要:[Figure not available: see fulltext.](#br)A series of 3-(adamantan-1-ylalkyl)-2-( O , S , Se )hydantoins were synthesized in the reaction of (adamantan-1-ylalkyl)heteroallenes with glycine ethyl ester hydrochloride under mild conditions in 75–85% yields. A method was develop...
作者:... Robert R. Fayzullin , Gennady M. Butov , Bruce D. Hammock
来源:[J].Bioorganic & Medicinal Chemistry Letters(IF 2.338), 2018, Vol.28 (13), pp.2302-2313Elsevier
摘要:Abstract(#br)A series of inhibitors of the soluble epoxide hydrolase (sEH) containing one or two thiourea groups has been developed. Inhibition potency of the described compounds ranges from 50 μM to 7.2 nM. 1,7-(Heptamethylene)bis[(adamant-1-yl)thiourea] ( 6f ) was found to...
作者:... Victor B. Rybakov , Gennady M. Butov , Bruce D. Hammock
来源:[J].Journal of Fluorine Chemistry(IF 1.939), 2019, Vol.220, pp.48-53Elsevier
摘要:Abstract(#br)A series of soluble epoxide hydrolase (sEH) inhibitors containing 2-fluorophenyl fragment was developed. Inhibition potency of the described compounds ranges from 0.7 to 630.9 nM. 1-(Adamantan-1-ylmethyl)-3-(2-fluorophenyl) urea ( 3b , IC 50 = 0.7 nM) and 1-(adamanta...
作者:Gennady M. Butov , Vladimir A. Palyulin ...
来源:[J].Bioorganic Chemistry(IF 1.732), 2019, Vol.87, pp.629-637Elsevier
摘要:Abstract(#br)Infections caused by flaviviruses pose a huge threat for public health all over the world. The search for therapeutically relevant compounds targeting tick-borne flaviviruses requires the exploration of novel chemotypes. In the present work a large series of novel po...
作者:... Tatiana Shkineva , Gennady M. Butov , Bruce D. Hammock
来源:[J].Bioorganic & Medicinal Chemistry Letters(IF 2.338), 2015, Vol.25 (23), pp.5514-5519Elsevier
摘要:Abstract(#br)Adamantyl ureas are good soluble epoxide hydrolase (sEH) inhibitors; however they have limited solubility and rapid metabolism, thus limiting their usefulness in some therapeutic indications. Herein, we test the hypothesis that nodal substitution on the adamantane wi...
作者:... Todd R. Harris , Gennady M. Butov , Bruce D. Hammock
来源:[J].Bioorganic & Medicinal Chemistry Letters(IF 2.338), 2014, Vol.24 (9), pp.2193-2197Elsevier
摘要:Abstract(#br)A series of inhibitors of the soluble epoxide hydrolase (sEH) containing two urea groups has been developed. Inhibition potency of the described compounds ranges from 2.0 μM to 0.4 nM. 1,6-(Hexamethylene)bis[(adamant-1-yl)urea] ( 3b ) was found to be a potent sl...
作者:Gennady M. Butov , Margarita E. Neganova ...
来源:[J].Bioorganic & Medicinal Chemistry(IF 2.903), 2016, Vol.24 (4), pp.712-720Elsevier
摘要:Abstract(#br)A versatile synthesis of novel 5-hydroxylaminoisoxazoles bearing adamantane moieties has been accomplished using the heterocyclization reactions of readily available unsaturated esters by the treatment with tetranitromethane in the presence of triethylamine and ...

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