全部文献期刊会议图书|学者科研项目
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作者:... Shaney L. Barratt , Gavin I. Welsh , Ann B. Millar
来源:[J].Respiratory Research(IF 3.642), 2017, Vol.18 (1)
摘要:Alternative splicing of Vascular endothelial growth factor-A mRNA transcripts (commonly referred as VEGF) leads to the generation of functionally differing isoforms, the relative amounts of which have potentially significant physiological outcomes in conditions such as acute resp...
作者:... Rachel Lennon , Gavin I. Welsh , Richard J. M. Coward
来源:[J].Diabetologia(IF 6.487), 2017, Vol.60 (11), pp.2299-2311
摘要:Podocytes are insulin - responsive cells of the glomerular filtration barrier and are key in preventing albuminuria, a hallmark feature of diabetic nephropathy. While there is evidence that a loss of insulin signalling to podocytes is detrimental, the molecular mechanisms underpi...
作者:... Ania B. Koziell , Gavin I. Welsh , Moin A. Saleem
来源:[J].Kidney International(IF 7.916), 2017, Vol.91 (4), pp.937-947
摘要:Steroid Resistant Nephrotic Syndrome (SRNS) in children and young adults has differing etiologies with monogenic disease accounting for 2.9–30% in selected series. Using whole exome sequencing we sought to stratify a national population of children with SRNS into monogenic a...
作者:Gavin I. Welsh , C. Charles Michel ...
来源:[J].Kidney International(IF 7.916), 2018, Vol.93 (5), pp.1086-1097
摘要:Increased urinary albumin excretion is a key feature of glomerular disease but has limitations as a measure of glomerular permeability. Here we describe a novel assay to measure the apparent albumin permeability of single capillaries in glomeruli, isolated from perfused kidneys c...
作者:Gavin I. Welsh , Moin A. Saleem
来源:[J].Acta Biomaterialia(IF 5.093), 2018, Vol.78, pp.111-122
摘要:Abstract(#br)Recreating tissue-specific microenvironments of the extracellular matrix (ECM) in vitro is of broad interest for the fields of tissue engineering and organ-on-a-chip. Here, we present biofunctional ECM protein fibres and suspended membranes, with tuneable bioche...
作者:Gavin I. Welsh , Rebecca R. Foster
来源:[J].Kidney International(IF 7.916), 2019
摘要:The endothelial glycocalyx is a key component of the glomerular filtration barrier. We have shown that matrix metalloproteinase (MMP)-mediated syndecan 4 shedding is a mechanism of glomerular endothelial glycocalyx damage in vitro , resulting in increased albumin permeability. He...
作者:Gavin I. Welsh , Rebecca R. Foster ...
来源:[J].Kidney International(IF 7.916), 2019, Vol.95 (1), pp.94-107
摘要:Aldosterone contributes to end-organ damage in heart failure and chronic kidney disease. Mineralocorticoid-receptor inhibitors limit activation of the receptor by aldosterone and slow disease progression, but side effects, including hyperkalemia, limit their clinical use. Da...
作者:Katherine A. Birchenall , Gavin I. Welsh , Andrés López Bernal
来源:[J].International Journal of Environmental Research and Public Health(IF 1.998), 2019, Vol.16 (9)
摘要:The mechanism of human labour remains poorly understood, limiting our ability to manage complications of parturition such as preterm labour and induction of labour. In this study we have investigated the effect of labour on plasma metabolites immediately following delivery, ...
作者:Gavin I. Welsh , G. Raghu ...
来源:[J].Archives of Biochemistry and Biophysics(IF 3.37), 2016, Vol.590, pp.10-19
摘要:Abstract(#br)Advanced glycation end-products (AGEs) are implicated in the pathogenesis of diabetic nephropathy (DN). N-carboxymethyl-lysine (CML) is one of the predominant AGEs that accumulate in all renal compartments of diabetic patients. Nevertheless, the direct effect of...

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