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作者:Günter Lambrecht , Jan Gross , Ernst Mutschler
来源:[J].Life Sciences(IF 2.555), 1999, Vol.64 (6), pp.403-410
摘要:Abstract(#br)A variety of neurons in gastrointestinal and genitourinary smooth muscle express muscarinic auto- as well as heteroreceptors. These receptors are found on the soma and dendrites of many cholinergic, sympathetic and NANC neurons and on axon terminals. A given neu...
作者:Günter Lambrecht , Jürgen Rettinger ...
来源:[J].European Journal of Pharmacology(IF 2.592), 2000, Vol.387 (3), pp.R19-R21
摘要:Abstract(#br)Pyridoxal-5′-phosphate-6-(2′-naphthylazo-6′-nitro-4′,8′-disulfonate) (PPNDS) potently antagonized P2X 1 receptor-mediated responses in rat vas deferens (p K B =7.43) and Xenopus laevis oocytes (pIC 50 =7.84). It showed lower (up to 20,000-fold) inhibit...
作者:... Günther Schmalzing , Günter Lambrecht , Fritz Markwardt
来源:[J].European Journal of Pharmacology(IF 2.592), 2000, Vol.387 (3), pp.245-252
摘要:Abstract(#br)The effect of the suramin analogue 8,8′-(carbonylbis(imino-4,1-phenylenecarbonylimino-4,1-phenylenecarbonylimino))bis(1,3,5-naphthalenetrisulfonic acid) (NF279) was analyzed on human P2X 1 and P2X 7 receptor subtypes (human P2X 1 and human P2X 7 ) heterologously...
作者:... Ulrich Moser , Ernst Mutschler , Günter Lambrecht
来源:[J].European Journal of Pharmacology(IF 2.592), 1995, Vol.286 (3), pp.229-240
摘要:Abstract(#br)The present study was designed to determine the in vitro affinity profile of ( R )-(−)-dimethindene and ( S )-(+)-dimethindene at muscarinic receptor subtypes using both functional and binding assays. In addition, the racemate was investigated in functional stud...
作者:... Jürgen Rettinger , Ernst Mutschler , Günter Lambrecht
来源:[J].European Journal of Pharmacology(IF 2.592), 1998, Vol.350 (1), pp.R5-R6
摘要:Abstract(#br)8,8′-(Carbonylbis(imino-4,1-phenylenecarbonylimino-4,1-phenylenecarbonylimino))bis(1,3,5-naphthalenetrisulfonic acid) (NF279) antagonized P2X receptor-mediated contractions in rat vas deferens, evoked by α , β -methylene ATP (10 μ M; p IC 50 =5.71) without ...
作者:... Jan Gross , Ernst Mutschler , Günter Lambrecht
来源:[J].Journal of Organometallic Chemistry(IF 2), 1996, Vol.521 (1), pp.305-323
摘要:Abstract(#br)The (hydroxymethyl)diorgano(2-piperidinoethyl)germanes rac -Ph( c -Hex)Ge(CH 2 OH)CH 2 CH 2 NR 2 ( rac - 1a ), Ph 2 Ge(CH 2 OH)CH 2 -CH 2 NR 2 ( 3a ) and ( c -Hex) 2 Ge(CH 2 OH)CH 2 CH 2 NR 2 ( 5a ) (NR 2 = piperidino) were synthesized starting from Cl 3 GeCH 2 ...
作者:... Wiro Menge , Hendrik Timmerman , Günter Lambrecht
来源:[J].European Journal of Pharmacology(IF 2.592), 1996, Vol.303 (3), pp.221-226
摘要:Abstract(#br)We investigated the binding and pharmacological properties of the esters of 3,3-dimethylbutan-1-ol (the carbon analogue of choline) with either diphenylglycolic acid, ( R )-phenylcyclohexylglycolic acid, or ( S )-phenylcyclohexylglycolic acid [BS-6181, (R)-BS-78...
作者:... Christine Keim , Ernst Mutschler , Günter Lambrecht
来源:[J].Journal of Organometallic Chemistry(IF 2), 2001, Vol.640 (1), pp.140-165
摘要:Abstract(#br)The C/Si/Ge-analogous compounds rac -Ph( c -C 5 H 9 )El(CH 2 OH)CH 2 CH 2 NR 2 (NR 2 =piperidino; El=C, rac - 3a ; El=Si, rac - 3b ; El=Ge, rac - 3c ) and ( c -C 5 H 9 ) 2 El(CH 2 OH)CH 2 CH 2 NR 2 (NR 2 =piperidino; El=C, 5a ; El=Si, 5b ; El=Ge, 5c ) were prepa...
作者:... Günther Schmalzing , Günter Lambrecht , Fritz Markwardt
来源:[J].European Journal of Pharmacology(IF 2.592), 2003, Vol.470 (1), pp.1-7
摘要:Abstract(#br)The antagonistic effects of the novel suramin analogue 4,4′,4″,4‴-(carbonylbis(imino-5,1,3-benzenetriylbis(carbonylimino)))tetrakis-benzene-1,3-disulfonic acid (NF449) were analyzed at homomeric human P2X 1 and P2X 7 receptor subtypes (hP2X 1 and hP2X 7 ) h...
作者:... Jan Gross , Ernst Mutschler , Günter Lambrecht
来源:[J].Journal of Organometallic Chemistry(IF 2), 1995, Vol.505 (1), pp.73-79
摘要:Abstract(#br)The unsaturated HHSiD ( 1 ) and p -F-HHSiD ( 2 ) derivatives ( E )-cyclohexyl(phenyl)(3-piperidino-1-propen-1-yl)silanol ( 5 , isolated as 5 · HCl) and ( E )-cyclohexyl(4-fluorophenyl)(3-piperidino-1-propen-1-yl)silanol ( 6 , isolated as 6 · HCl) were synthesize...

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