全部文献期刊会议图书|学者科研项目
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作者:Francis Rousset , Leilei Zhang ...
来源:[J].Biochemical and Biophysical Research Communications(IF 2.406), 2020, Vol.521 (2), pp.383-388
摘要:Abstract(#br)The NADPH oxidase Nox4 is a multi-pass membrane protein responsible for the generation of reactive oxygen species that are implicated in cellular signaling but may also cause pathological situations when dysregulated. Although topological organization of integral mem...
作者:Francis Rousset , German Nacher-Soler ...
来源:[J].Redox Biology, 2020, Vol.30
摘要:Abstract(#br)Age-related hearing (ARHL) loss affects a large part of the human population with a major impact on our aging societies. Yet, underlying mechanisms are not understood, and no validated therapy or prevention exists. NADPH oxidases (NOX), are important sources of react...
作者:Francis Rousset , Patrick Salmon ...
来源:[J].Molecular Therapy - Nucleic Acids, 2018
摘要:Abstract(#br)Synthetic miRNA minigenes, SMIG, have a major potential for molecular therapy, however their optimal architecture still needs to be determined. We have previously optimized the stem structure of miRNA hairpins for efficient gene knockdown. Here we investigate th...
作者:Francis Rousset , Minh Vu Chuong Nguyen ...
来源:[J].PLoS ONE(IF 3.73), 2017, Vol.8 (6)
摘要:Interleukin-1β (IL-1β) activates the production of reactive oxygen species (ROS) and secretion of MMPs as well as chondrocyte apoptosis. Those events lead to matrix breakdown and are key features of osteoarthritis (OA). We confirmed that in human C-20/A4 chondrocytes the NAD...
作者:Francis Rousset , Florence Hazane-Puch ...
来源:[J].Biochemical Pharmacology(IF 4.576), 2013, Vol.85 (11), pp.1644-1654
摘要:Abstract(#br)NADPH oxidase Nox4 is expressed in a wide range of tissues and plays a role in cellular signaling by providing reactive oxygen species (ROS) as intracellular messengers. Nox4 oxidase activity is thought to be constitutive and regulated at the transcriptional lev...
作者:Francis Rousset , Monique Talbot ...
来源:[J].Biochimie(IF 3.142), 2011, Vol.93 (3), pp.457-468
摘要:Abstract(#br)Nox4, a member of Nox family of NADPH oxidase expressed in nonphagocytic cells, is a major source of reactive oxygen species in many cell types. But understanding of the role of Nox4 in the production of ROS and of regulation mechanism of oxidase activity is lar...
作者:Francis Rousset , Stephanie Carnesecchi ...
来源:[J].Current Pharmaceutical Design(IF 3.311), 2015, Vol.21 (41), pp.5977-5987
摘要:Inner ear pathologies are associated with major morbidity and loss of life quality in affected patients. Inmany of these conditions, production of reactive oxygen-species (ROS) is thought to be a key pathological mechanism.While the sources of ROS are complex (including for examp...
作者:Francis Rousset , Stephanie Carnesecchi ...
来源:[J].Current Pharmaceutical Design(IF 3.311), 2015, Vol.21 (41), pp.5977-5987
摘要:Inner ear pathologies are associated with major morbidity and loss of life quality in affected patients. Inmany of these conditions, production of reactive oxygen-species (ROS) is thought to be a key pathological mechanism.While the sources of ROS are complex (including for examp...
作者:Francis Rousset , Minh Vu Chuong Nguyen ...
来源:[J].PLOS ONE(IF 3.73), 2013, Vol.8 (6)
摘要:Interleukin-1β (IL-1β) activates the production of reactive oxygen species (ROS) and secretion of MMPs as well as chondrocyte apoptosis. Those events lead to matrix breakdown and are key features of osteoarthritis (OA). We confirmed that in human C-20/A4 chondrocytes the NAD...
作者:Francis Rousset , Sylvie Berthier ...
来源:[J].médecine/sciences(IF 0.556), 2015, Vol.31 (1), pp.43-52
摘要:La famille des NADPH oxydases, Nox, chez l’homme, est composée de sept isoenzymes, cinq Nox et deux Duox ( dual oxidase ). Leur unique fonction est de réduire l’oxygène moléculaire pour synthétiser l’anion superoxyde et les espèces radicalaires, ROS ( reactive oxyg...

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