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作者:... Bernard Lardy , Françoise Morel , Minh Vu Chuong Nguyen
来源:[J].Biochemical and Biophysical Research Communications(IF 2.406), 2020, Vol.521 (2), pp.383-388
摘要:Abstract(#br)The NADPH oxidase Nox4 is a multi-pass membrane protein responsible for the generation of reactive oxygen species that are implicated in cellular signaling but may also cause pathological situations when dysregulated. Although topological organization of integral mem...
作者:Françoise Morel , Marie-Hélène Paclet ...
来源:[J].Free Radical Biology and Medicine(IF 5.271), 2018, Vol.116, pp.41-49
摘要:Abstract(#br)The p22 phox protein is an essential component of the phagocytic- and inner ear NADPH oxidases but its relationship to other Nox proteins is less clear. We have studied the role of p22 phox in the TGF-β1-stimulated H 2 O 2 production of primary human and murine ...
作者:... Marie-Hélène Paclet , Benoît Polack , Françoise Morel
来源:[J].PLoS ONE(IF 3.73), 2017, Vol.7 (7)
摘要:S100A8 and S100A9 are two calcium binding Myeloid Related Proteins, and important mediators of inflammatory diseases. They were recently introduced as partners for phagocyte NADPH oxidase regulation. However, the precise mechanism of their interaction remains elusive. We had for ...
作者:... Romy Rothe , Françoise Morel , Jean-Luc Lenormand
来源:[J].PLoS ONE(IF 3.73), 2017, Vol.2 (9)
摘要:BACKGROUND: Gp91(phox) is a transmembrane protein and the catalytic core of the NADPH oxidase complex of neutrophils. Lack of this protein causes chronic granulomatous disease (CGD), a rare genetic disorder characterized by severe and recurrent infections due to the incapacity of...
作者:... Laurent Grange , Françoise Morel , Bernard Lardy
来源:[J].PLoS ONE(IF 3.73), 2017, Vol.8 (6)
摘要:Interleukin-1β (IL-1β) activates the production of reactive oxygen species (ROS) and secretion of MMPs as well as chondrocyte apoptosis. Those events lead to matrix breakdown and are key features of osteoarthritis (OA). We confirmed that in human C-20/A4 chondrocytes the NAD...
作者:... Marie-Noëlle Hilleret , Françoise Morel , Jean-Pierre Zarski
来源:[J].Journal of Hepatology(IF 9.858), 2014, Vol.61 (1), pp.28-34
摘要:Background & Aims(#br)Fibrosis blood tests have been validated in chronic hepatitis C. Their diagnostic accuracy is less documented in hepatitis B. The aim of this study was to describe the diagnostic performance of FibroTest®, FibroMeter®, and HepaScore® for liver fibrosis ...
作者:... Lena Serrander , Karl-Heinz Krause , Françoise Morel
来源:[J].Biochemical Pharmacology(IF 4.576), 2013, Vol.85 (11), pp.1644-1654
摘要:Abstract(#br)NADPH oxidase Nox4 is expressed in a wide range of tissues and plays a role in cellular signaling by providing reactive oxygen species (ROS) as intracellular messengers. Nox4 oxidase activity is thought to be constitutive and regulated at the transcriptional lev...
作者:... Jean-Luc Lenormand , Bernard Lardy , Françoise Morel
来源:[J].Biochemical and Biophysical Research Communications(IF 2.406), 2012, Vol.419 (3), pp.453-458
摘要:Abstract(#br)The membrane protein NADPH (nicotinamide adenine dinucleotide phosphate) oxidase Nox4 constitutively generates reactive oxygen species differing from other NADPH oxidases activity, particularly in Nox2 which needs a stimulus to be active. Although the precise me...
作者:... Marie-Hélène Paclet , GuanXiang Qian , Françoise Morel
来源:[J].Biochimie(IF 3.142), 2011, Vol.93 (3), pp.457-468
摘要:Abstract(#br)Nox4, a member of Nox family of NADPH oxidase expressed in nonphagocytic cells, is a major source of reactive oxygen species in many cell types. But understanding of the role of Nox4 in the production of ROS and of regulation mechanism of oxidase activity is lar...
作者:Françoise Morel , Stéphane Arbault
来源:[J].Biochemical and Biophysical Research Communications(IF 2.406), 2007, Vol.361 (2), pp.493-498
摘要:Abstract(#br)Oxidative stress is a metabolic situation used by immune cells to provide protection against infection. Under activation by threatening elements, phagocytes produce chemically toxic molecules, namely the reactive oxygen species (ROS) and reactive nitrogen species (RN...

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