全部文献期刊会议图书|学者科研项目
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作者:Françoise Hinnen , Chantal Fuseau
来源:[J].Nuclear Medicine and Biology(IF 2.517), 1999, Vol.26 (1), pp.105-109Elsevier
摘要:Abstract(#br)ABSTRACT. (±)-3-[ 11 C]Methyl-2-[4-[3-( tert -butylamino)-2-hydroxypropoxy]phenyl]-6-methoxy-4( 3H )-quinazolinone ([±]-[ 11 C]HX-CH 44) was labeled with carbon-11 using [ 11 C]iodomethane with the corresponding N -demethylated precursor. Then, 30–90 mCi (1...
作者:Françoise Hinnen , Christine Coulon ...
来源:[J].Journal of Pharmaceutical Sciences(IF 3.13), 2008, Vol.97 (7), pp.2811-2819Elsevier
摘要:Abstract(#br)In vivo pharmacokinetic and brain binding characteristics of (+)-[ 11 C]A-69024, a high-affinity-D1-selective dopamine receptor antagonist, were assessed with micro-PET and β-microprobes in the rat and PET in the baboon. The biodistribution of (+)-[ 11 C]A-69024...
作者:Françoise Hinnen , Chantal Fuseau ...
来源:[J].Life Sciences(IF 2.555), 1998, Vol.64 (5), pp.PL93-PL97Elsevier
摘要:Abstract(#br)The biodistribution of the nicotinic acetylcholine receptor (nAChR) radioligand 2-[ 18 F]fluoro-3-[2(S)-2-azetidinylmethoxy]pyridine ([ 18 F]fluoro-A-85380, half-life of fluorine-18 = 110 min) in selected rat brain areas was assessed in vivo. The radiotracer showed a...
作者:Françoise Hinnen , Myriam Berrehouma ...
来源:[J].Bioorganic & Medicinal Chemistry(IF 2.903), 2003, Vol.11 (13), pp.2769-2782Elsevier
摘要:Abstract(#br)In recent years, considerable effort has been spent on the design, synthesis and pharmacological characterization of radiofluorinated derivatives of the 5-HT 1A receptor antagonist, WAY-100635, for the in vivo study of these receptors in human brain with PET. ( ...
作者:... Michel Bottlaender , Françoise Hinnen , Daniel Marzin
来源:[J].Nuclear Medicine and Biology(IF 2.517), 2002, Vol.29 (8), pp.849-853Elsevier
摘要:Abstract(#br)The potential mutagenic properties (micronucleus and the Ames tests) of fluoro-A-85380 (2-fluoro-3-[2(S)-2-azetidinylmethoxy]pyridine) were evaluated as a mandatory pre-clinical step. No statistically significant increase in the frequency of micronucleated polychroma...
作者:Françoise Hinnen , Frédéric Dollé ...
来源:[J].Nuclear Medicine and Biology(IF 2.517), 2004, Vol.31 (1), pp.103-110Elsevier
摘要:Abstract(#br)(1R,2S)-4-[ 18 F]fluorometaraminol (4-[ 18 F]FMR), a tracer for cardiac sympathetic innervation, was synthesized by electrophilic aromatic substitution. A trimethylstannyl precursor, protected with tert -butoxycarbonyl protecting groups, was radiofluorinated wit...
作者:Françoise Hinnen , Stéphane Demphel ...
来源:[J].Applied Radiation and Isotopes(IF 1.179), 2005, Vol.64 (3), pp.348-354Elsevier
摘要:Abstract(#br)Recently, a novel series of amidines has been described, exhibiting high NR2B-subtype selective N -methyl- D -aspartate (NMDA) antagonist activity with nanomolar or subnanomolar affinity. Within the styrylamidine subclass, ( E )- N -(2-methoxybenzyl)-3-phenyl-ac...
作者:Françoise Hinnen , Héric Valette ...
来源:[J].Bioorganic & Medicinal Chemistry(IF 2.903), 1997, Vol.5 (4), pp.749-764Elsevier
摘要:Abstract(#br)(±)-S11568 ( 1 . 3-ethyl-5-methyl-(±)-2-[(2-(2-aminoethoxy)ethoxy)methyl]-4-(2,3-dichlorophenyl)-6-methyl-1,4-dihydropyridine-3,5- dicarboxylate), has an in vitro profile of high potency and of high electivity for the low-voltage dependent L-type calcium channel...
作者:Françoise Hinnen , Françoise Vaufrey ...
来源:[J].Bioorganic & Medicinal Chemistry(IF 2.903), 2002, Vol.10 (8), pp.2611-2623Elsevier
摘要:Abstract(#br)Considerable efforts have been engaged in the design, synthesis and pharmacological characterization of radioligands for imaging the serotonin transporter, based on its implication in several neuropsychiatric diseases, such as depression, anxiety and schizophren...
作者:Françoise Hinnen , Christine Coulon ...
来源:[J].Bioorganic & Medicinal Chemistry(IF 2.903), 2006, Vol.14 (11), pp.3848-3858Elsevier
摘要:Abstract(#br)FPhEP ( 1 , (+/−)-2- exo -(2′-fluoro-3′-phenyl-pyridin-5′-yl)-7-azabicyclo[2.2.1]heptane) belongs to a recently described novel series of 3′-phenyl analogues of epibatidine, which not only possess subnanomolar affinity and high selectivity for brain α4...

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