全部文献期刊学位论文会议报纸专利标准年鉴图书|学者科研项目
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作者:Frédéric Dollé , Juha O. Rinne ...
来源:[J].Molecular Imaging and Biology(IF 3.095), 2017, Vol.19 (5), pp.736-745Springer
摘要:Many neurological conditions result in the overexpression of the translocator protein 18 kDa (TSPO), today recognized as a biomarker for microglial activation and neuroinflammation imaging. The pyrazolo[1,5-a]pyrimidine acetamides are a particularly attractive class of TSPO-speci...
作者:Frédéric Dollé , Martine Guillermier ...
来源:[J].PLoS ONE(IF 3.73), 2018, Vol.8 (1)DOAJ
摘要:The development of dyskinesias following chronic L-DOPA replacement therapy remains a major problem in the long-term treatment of Parkinson's disease. This study aimed at evaluating the effect of IRC-082451 (base of BN82451), a novel multitargeting hybrid molecule, on L-DOPA-indu...
作者:Frédéric Dollé , Frank Marguet ...
来源:[J].European Journal of Medicinal Chemistry(IF 3.499), 2017, Vol.125, pp.346-359Elsevier
摘要:Abstract(#br)The translocator protein 18 kDa (TSPO) is today a validated target for a number of therapeutic applications, but also a well-recognized diagnostic/imaging biomarker for the evaluation of inflammatory related-disease state and progression, prompting the developme...
作者:Frédéric Dollé , Jean-Michel Scherrmann ...
来源:[J].The AAPS Journal(IF 4.386), 2013, Vol.15 (4), pp.1082-1090Springer
摘要:Abstract(#br)Glyburide (glibenclamide, GLB) is a widely prescribed antidiabetic with potential beneficial effects in central nervous system injury and diseases. In vitro studies show that GLB is a substrate of organic anion transporting polypeptide (OATP) and ATP-binding cas...
作者:Frédéric Dollé , Bertrand Kuhnast ...
来源:[J].European Journal of Medicinal Chemistry(IF 3.499), 2015, Vol.92, pp.818-838Elsevier
摘要:Abstract(#br)Melanin pigment represents an attractive target to address specific treatment to melanoma cells, such as cytotoxic radionuclides. However, less than half of the patients have pigmented metastases. Hence, specific marker is required to stratify this patient popul...
作者:... Frank Marguet , Frédéric Puech , Frédéric Dollé
来源:[J].European Journal of Medicinal Chemistry(IF 3.499), 2015, Vol.101, pp.736-745Elsevier
摘要:Abstract(#br)SSR180575 ( 1 ) is a high-affinity (0.83 nM) TSPO 18 kDa ligand belonging to the pyridazino[4,5- b ]indole-1-acetamides family. Herein we describe the synthesis and in vitro characterization of two series of new fluorinated analogues. Eleven compounds (out of fi...
作者:... Frédéric Puech , Raphaël Boisgard , Frédéric Dollé
来源:[J].Bioorganic & Medicinal Chemistry Letters(IF 2.338), 2014, Vol.24 (6), pp.1550-1556Elsevier
摘要:Abstract(#br)A series of four novel analogues of DPA-714, bearing a fluoroalkynyl side chain (with a length ranging from three to six carbon atoms) in replacement of the fluoroethoxy motif, have been synthetized in six steps from commercially available methyl 4-iodobenzoate....
作者:Frédéric Dollé , Bertrand Kühnast
来源:[J].Molecular Imaging and Biology(IF 3.095), 2016, Vol.18 (4), pp.617-626Springer
摘要:Abstract(#br) Purpose(#br)Transgenic mice expressing the polyoma middle T oncoprotein (PyMT) in the mammary epithelium were explored by multimodal imaging to monitor longitudinally spontaneous tumor growth and response to chemotherapy.(#br) Procedures(#br)Positron emission t...
作者:... Marie-Anne Peyronneau , Frédéric Dollé , Raphaël Boisgard
来源:[J].Molecular Imaging and Biology(IF 3.095), 2016, Vol.18 (1), pp.127-134Springer
摘要:Abstract(#br) Purpose(#br)Many radioligands have been explored for imaging the 18-kDa translocator protein (TSPO), a diagnostic and therapeutic target for inflammation and cancer. Here, we investigated the TSPO radioligand [18F]DPA-714 for positron emission tomography ...

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