全部文献期刊学位论文会议报纸专利标准年鉴图书|学者科研项目
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作者:Fen-Fen Lin , Sakthivel Muniyan ...
来源:[J].Cell & Bioscience(IF 3), 2015, Vol.5 (1)Springer
摘要:Abstract(#br) Background(#br)Prostate cancer (PCa) is the most commonly diagnosed solid tumor and the second leading cancer death in the United States, and also one of the major cancer-related deaths in Chinese. Androgen deprivation therapy (ADT) is the first line treatment for m...
作者:Fen-Fen Lin , Shi-Yuan Meng ...
来源:[J].Bioorganic & Medicinal Chemistry Letters(IF 2.338), 2015, Vol.25 (21), pp.4866-4871Elsevier
摘要:Abstract(#br)Many efforts are underway to develop selective inhibitors of the voltage-gated sodium channel Na V 1.7 as new analgesics. Thus far, however, in vitro selectivity has proved difficult for small molecules, and peptides generally lack appropriate pharmacokinetic pr...
作者:Fen-Fen Lin , Hung Q. Nguyen ...
来源:[J].Journal of Immunotoxicology(IF 1.571), 2015, Vol.12 (2), pp.164-173Taylor & Francis
摘要:Abstract(#br)ORAI1 is the pore-forming component of calcium release-activated calcium (CRAC) channels. CRAC channels are the primary route for calcium ion (Ca2+) entry into T-cells following antigen stimulation. This Ca2+ entry induces proliferation and cyto...
作者:Fen-Fen Lin , Dharam Kaushik ...
来源:[J].Cancer Letters(IF 4.258), 2011, Vol.311 (2), pp.177-186Elsevier
摘要:Abstract(#br)We identified the molecular target by histone deacetylase (HDAC) inhibitors for exploring their potential prostate cancer (PCa) therapy. Upon HDAC inhibitors-treatment, LNCaP cell growth was suppressed, correlating with increased cellular prostatic acid phosphatase (...
作者:Fen-Fen Lin , Karen Lariosa-Willingham ...
来源:[J].Journal of Neuroimmunology(IF 3.033), 2004, Vol.153 (1), pp.108-121Elsevier
摘要:Abstract(#br)FTY720 is a prodrug for FTY-phosphate, an agonist at four of the five known receptors for sphingosine-1-phosphate (S1P). We show that administration of either FTY720 or FTY-P to SJL mice with established relapsing–remitting experimental autoimmune encephalitis (...
作者:... Ming-Shyue Lee , Renee Garcia-Arenas , Fen-Fen Lin
来源:[J].Cell Biology International(IF 1.64), 2000, Vol.24 (10), pp.681-689Elsevier
摘要:Abstract(#br)Androgens regulate the expression of both human prostatic acid phosphatase (PAcP) and prostate-specific antigen (PSA), two major prostate epithelium-specific differentiation antigens. Due to the important role of these two enzymes as prostate epithelium differen...
作者:Fen-Fen Lin , Naichen Yu ...
来源:[J].International Journal of Developmental Neuroscience(IF 2.692), 2004, Vol.22 (3), pp.131-135Elsevier
摘要:Abstract(#br)Reactive gliosis is an aspect of neural plasticity and growth factor (GF) stimulation of astrocytes in vitro is widely regarded as a model system to study astrocyte plasticity. Astrocytes express receptors for several ligands including lysophosphatidic acid (LPA) and...
作者:Fen-Fen Lin , Rachel Schutte ...
来源:[J].Cancer Letters(IF 4.258), 2009, Vol.285 (1), pp.58-65Elsevier
摘要:Abstract(#br)We examined the efficacy of combination treatments utilizing cytotoxic drugs plus inhibitors to members of the ErbB–ERK signal pathway in human prostate cancer (PCa) LNCaP C-81 cells. Under an androgen-reduced condition, 50 nM gemcitabine caused about 40% growth...
作者:Fen-Fen Lin , Emma L Palfreyman ...
来源:[J].Brain Research(IF 2.879), 2003, Vol.990 (1), pp.182-194Elsevier
摘要:Abstract(#br)Lysophosphatidic acid (1-acyl-2-lyso- sn -glycero-3-phosphate; LPA) and sphingosine-1-phosphate (S1P) are bioactive phospholipids which respectively act as agonists for the G-protein-coupled lp A receptors (LPA1, LPA2, and LPA3) and s1p receptors (S1P1, S1P2, S1...
作者:Fen-Fen Lin , Dinlii Lin ...
来源:[J].Molecular and Cellular Endocrinology(IF 4.039), 1995, Vol.111 (1), pp.29-37Elsevier
摘要:Abstract(#br)The expression of prostatic acid phosphatase (PAcP) in three human prostate carcinoma cell lines including LNCaP, DU 145 and PC-3, was studied to explore its potential role as a marker in the progression of prostate cancer. Although Southern blot analysis suggested t...

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