全部文献期刊会议图书|学者科研项目
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作者:Fabrizio Pucci , Marianne Rooman
来源:[J].Current Opinion in Structural Biology(IF 8.738), 2017, Vol.42, pp.117-128
摘要:The molecular bases of thermal and cold stability and adaptation, which allow proteins to remain folded and functional in the temperature ranges in which their host organisms live and grow, are still only partially elucidated. Indeed, both experimental and computational studies f...
作者:Fabrizio Pucci , Alexander Schug
来源:[J].Methods(IF 3.641), 2019, Vol.162-163, pp.68-73
摘要:Abstract(#br)Structured RNA plays many functionally relevant roles in molecular life. Structural information, while required to understand the functional cycles in detail, is challenging to gather. Computational methods promise to complement experimental efforts by predicting thr...
作者:Fabrizio Pucci , Marianne Rooman
来源:[J].BMC Genomics(IF 4.397), 2019, Vol.20 (S8), pp.1-11
摘要:Abstract Background It is nowadays clear that single base substitutions that occur in the human genome, of which some lead to pathogenic conditions, are non-random and influenced by their flanking nucleobase sequences. However, despite recent progress, the understanding of t...
作者:Fabrizio Pucci , Malik Dhanani ...
来源:[J].PLoS ONE(IF 3.73), 2017, Vol.9 (3)
摘要:The ability to rationally modify targeted physical and biological features of a protein of interest holds promise in numerous academic and industrial applications and paves the way towards de novo protein design. In particular, bioprocesses that utilize the remarkable proper...
作者:Fabrizio Pucci , Maxime Godfroid
来源:[J].Scientific Reports(IF 2.927), 2018, Vol.8 (1), pp.665-677
摘要:Abstract(#br)The classification of human genetic variants into deleterious and neutral is a challenging issue, whose complexity is rooted in the large variety of biophysical mechanisms that can be responsible for disease conditions. For non-synonymous mutations in structured prot...
作者:... Fabian Teheux , Fabrizio Pucci , Marianne Rooman
来源:[J].Scientific Reports(IF 2.927), 2019, Vol.9 (1), pp.1141-1149
摘要:Abstract(#br)Transmembrane proteins play a fundamental role in a wide series of biological processes but, despite their importance, they are less studied than globular proteins, essentially because their embedding in lipid membranes hampers their experimental characterizatio...
作者:Fabrizio Pucci , Raphaël Bourgeas , Marianne Rooman
来源:[J].Scientific Reports(IF 2.927), 2016, Vol.6 (1), pp.631-43
摘要:Abstract(#br)The accurate prediction of the impact of an amino acid substitution on the thermal stability of a protein is a central issue in protein science, and is of key relevance for the rational optimization of various bioprocesses that use enzymes in unusual conditions....
作者:Fabrizio Pucci
来源:[J].Journal of High Energy Physics, 2012, Vol.2012 (11), pp.1-29
摘要:A bstract (#br)We study supersymmetric ’t Hooft loop operators in $ \mathcal{N}=4 $ super Yang-Mills, generalizing the well-known circular 1/2 BPS case and investigating their S-duality properties. We derive the BPS condition for a generic line operator describing pointlike ...

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