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作者:Fabien Brossier , Peter Deplazes ...
来源:[J].BMC Genomics(IF 4.397), 2015, Vol.16 (1)Springer
摘要:Abstract(#br) Background(#br)The protozoan Eimeria tenella is a common parasite of chickens, causing avian coccidiosis, a disease of on-going concern to agricultural industries. The high prevalence of E. tenella can be attributed to the resilient oocyst stage, which is trans...
作者:Fabien Brossier , Yves Le Vern ...
来源:[J].PLoS ONE(IF 3.73), 2017, Vol.10 (2)DOAJ
摘要:E. tenella infection is associated with a severe intestinal disease leading to high economic losses in poultry industry. Mitogen activated protein kinases (MAPKs) are implicated in early response to infection and are divided in three pathways: p38, extracellular signal-regul...
作者:... Adrian B. Hehl , Fabien Brossier , Nicholas C. Smith
来源:[J].Parasites & Vectors(IF 3.246), 2016, Vol.9 (1)Springer
摘要:Abstract(#br) Background(#br) Eimeria is an important genus of apicomplexan parasites. A defining feature of these parasites is the oocyst, which is transmitted into the environment via the faeces of definitive hosts. The oocyst wall contains cross-linked, tyrosine-rich proteins ...
作者:Fabien Brossier , Mélanie Pénichon ...
来源:[J].Bioorganic & Medicinal Chemistry Letters(IF 2.338), 2016, Vol.26 (1), pp.114-120Elsevier
摘要:Abstract(#br)Screening of our chemical library to discover new molecules exhibiting in vitro activity against the invasion of host cells by Eimeria tenella revealed a lead compound with an IC 50 of 15 μM. Structure–activity relationship studies were conducted with 34 newly s...
作者:Fabien Brossier , Alain Gueiffier ...
来源:[J].European Journal of Medicinal Chemistry(IF 3.499), 2015, Vol.89, pp.386-400Elsevier
摘要:Abstract(#br)An in vitro screening of the anti-apicomplexan activity of 51 compounds, stemming from our chemical library and from chemical synthesis, was performed. As a study model, we used Toxoplasma gondii ( T. gondii ), expressing β-galactosidase for the colorimetric ass...
作者:Fabien Brossier , L. David Sibley
来源:[J].International Journal of Biochemistry and Cell Biology(IF 4.152), 2005, Vol.37 (11), pp.2266-2272Elsevier
摘要:Abstract(#br)The phylum Apicomplexa contains parasites responsible for a variety of diseases including malaria, cryptosporidiosis, and toxoplasmosis. One of the common features of these parasites is that they contain a set of apical organelles whose sequential secretion is r...
作者:Fabien Brossier , Yves Le Vern ...
来源:[J].PLOS ONE(IF 3.73), 2015, Vol.10 (2)PLOS
摘要:E . tenella infection is associated with a severe intestinal disease leading to high economic losses in poultry industry. Mitogen activated protein kinases (MAPKs) are implicated in early response to infection and are divided in three pathways: p38, extracellular signal-regu...
作者:Fabien Brossier , Joel Shuman
来源:[J].PLOS Pathogens(IF 9.127), 2010, Vol.6 (4)PLOS
摘要:Host cell attachment by Toxoplasma gondii is dependent on polarized secretion of apical adhesins released from the micronemes. Subsequent translocation of these adhesive complexes by an actin-myosin motor powers motility and host cell invasion. Invasion and motility are also acco...
作者:... Nicholas C. Smith , Gilles Lalmanach , Fabien Brossier
来源:[J].PLOS ONE(IF 3.73), 2012, Vol.7 (3)PLOS
摘要:The invasion and replication of Eimeria tenella in the chicken intestine is responsible for avian coccidiosis, a disease that has major economic impacts on poultry industries worldwide. E. tenella is transmitted to naïve animals via shed unsporulated oocysts that need contac...

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