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作者:Eykmar Fett , Florence Goumy ...
来源:[J].Bioorganic & Medicinal Chemistry Letters(IF 2.338), 2016, Vol.26 (1), pp.25-32
摘要:Abstract(#br)Chemical modulation of a formerly disclosed DGAT-1 inhibitor resulted in the identification of a compound with a suitable profile for preclinical development. Optimisation of solubility is discussed and a PK/PD study is presented.
作者:Eykmar Fett , Florence Camy ...
来源:[J].Bioorganic & Medicinal Chemistry Letters(IF 2.338), 2012, Vol.22 (7), pp.2497-2502
摘要:Abstract(#br)A novel class of DGAT1 inhibitors containing a thiadiazole core has been discovered. Chemical optimization lead to inhibitors of human DGAT1 with an appropriate ADME profile and that show in vivo activity in target tissues.

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